Advertisement

Phytolacca americana L. and P. acinosa Roxb.

  • Weici Tang
  • Gerhard Eisenbrand

Abstract

Shanglu, Radix Phytolaccae, is the dry root of Phytolacca acinosa Roxb. or P. americana L. (Phytolaccaceae) collected in the spring and fall. This officially in the Chinese Pharmacopoeia listed herbal medicine is toxic and to be used for treatment of edema or treatment of abscess by external administration.

Keywords

Triterpene Alcohol Antiviral Protein Total Saponin Crude Saponin Pokeweed Antiviral Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ahmed ZF, Zufall CJ, Jenkins GL (1949) A contribution to the chemistry and toxicology of the root of Phytolacca americana. J Am Pharm Assoc 38:443–448Google Scholar
  2. 2.
    Stout GH, Malofsky BM, Stout VF (1964) Phytolaccagenin: a light atom X-ray structure proof using chemical information. J Am Chem Soc 86:957–958CrossRefGoogle Scholar
  3. 3.
    Woo WS, Kang SS, Wagner H, Seligmann O, Chari VM (1978) Triterpenoid saponins from the roots of Phytolacca americana. Planta Med 34:87–92CrossRefGoogle Scholar
  4. 4.
    Woo WS, Kang SS (1976) Phytolaccoside B: triterpene glycoside from Phytolacca americana. Phytochemistry 15:1315–1317CrossRefGoogle Scholar
  5. 5.
    Suga Y, Maruyama Y, Kawanishi S, Shoji J (1978) Studies on the constituents of phytolaccaceous plants. I. On the structures of phytolaccasaponin B, E and G from the roots of Phytolacca americana L. Chem Pharm Bull (Tokyo) 26:520–525Google Scholar
  6. 6.
    Kang SS, Woo WS (1987) Two new saponins from Phytolacca americana. Planta Med 53:338–340PubMedCrossRefGoogle Scholar
  7. 7.
    Woo WS, Kang SS (1977) The structure of phytolaccoside G. Yakhak Hoe Chi 21:159–162 (CA 88:191324h)Google Scholar
  8. 8.
    Kang SS, Woo WS (1980) Triterpenes from the berries of Phytolacca americana. J Nat Prod 43:510–513CrossRefGoogle Scholar
  9. 9.
    Burke DE, Le Quesne PW (1971) 3-Acetyloleanolic acid from Phytolacca americana seeds. Phytochemistry 10:3319–3320CrossRefGoogle Scholar
  10. 10.
    Woo WS, Wagner H (1977) 3-Acetylaleuritolic acid from the seeds of Phytolacca americana. Phytochemistry 16:1845–1846CrossRefGoogle Scholar
  11. 11.
    Woo WS (1974) Steroids and pentacyclic triterpenoids from Phytolacca americana. Phytochemistry 13:2887–2889CrossRefGoogle Scholar
  12. 12.
    Itoh T, Uetsuki T, Tamura T, Matsumoto T (1980) Characterization of triterpene alcohols of seed oils from some species of Theaceae, Phytolaccaceae and Sapotaceae. Lipids 15:407–411CrossRefGoogle Scholar
  13. 13.
    Woo WS, Kang SS, Wagner H, Chari VM (1978) The structure of americanin, a new neolignan from Phytolacca americana. Tetrahedron Lett 3239–3242Google Scholar
  14. 14.
    Lin LJ, Meksuriyen D, Cordell GA, Woo WS, Lee CK (1987) The structure of americanin A. Saengyak Hakhoechi 18:94–98 (CA 107:242496m)Google Scholar
  15. 15.
    Woo WS, Kang SS, Seligmann O, Chari VM, Wagner H (1980) The structure of new lignans from the seeds of Phytolacca americana. Tetrahedron Lett 21:4255–4258CrossRefGoogle Scholar
  16. 16.
    Hasegawa T, Fukuyama Y, Koshino K, Nakagawa K, Tori M, Asakawa Y (1987) Studies of isoamericanin A, a prostaglandin I2 inducer, isolated from the seeds of Phytolacca americana L. Chem Lett 329–332Google Scholar
  17. 17.
    Funayama S, Hikino H (1979) Hypotensive principles of Phytolacca roots. J Nat Prod 42:672–674PubMedCrossRefGoogle Scholar
  18. 18.
    Irvin JD, Kelly T, Robertus JD (1980) Purification and properties of a second antiviral protein from Phytolacca americana which inactivates eukaryotic ribosomes. Arch Biochem Biophys 200:418–425PubMedCrossRefGoogle Scholar
  19. 19.
    Houston LL, Ramakrishnan S, Hermodson MA (1983) Seasonal variations in different forms of pokeweed antiviral protein, a potent inactivator of ribosomes. J Biol Chem 258:9601–9604PubMedGoogle Scholar
  20. 20.
    Barbieri L, Aron GM, Irvin JD, Stirpe F (1982) Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed). Biochem J 203:55–59PubMedGoogle Scholar
  21. 21.
    Wyatt SD, Shepherd RJ (1969) Isolation and characterization of a virus inhibitor from Phytolacca americana. Phytopathology 59:1787–1794PubMedGoogle Scholar
  22. 22.
    Robertus JD, Monzingo AF, Irvin JD (1977) Preliminary X-ray diffraction studies on a antiviral protein. Biochem Biophys Res Commun 74:775–779PubMedCrossRefGoogle Scholar
  23. 23.
    Ready MP, Brown DT, Robertus JD (1986) Extracellular localization of pokeweed antiviral protein. Proc Natl Acad Sci USA 83:5053–5056PubMedCrossRefGoogle Scholar
  24. 24.
    Yi YH, Wang ZL (1984) Active principles of Phytolacca esculenta. I. Isolation and identification of the triterpene saponins. Chin Trad Herb Drugs 15:55–59Google Scholar
  25. 25.
    Wang ZL, Yi YH (1984) Studies on the active principles of the traditional Chinese drug “Shang Lu” (Phytolacca esculenta Van Houtte). II. Isolation and identification of esculentoside E and F. Acta Pharm Sin 19:825–829Google Scholar
  26. 26.
    Glombitza KW, Gielsdorf W, Eckhardt G, Koch ML (1975) Triterpenoid sapogenins from the fruits of Phytolacca acinosa. Planta Med 27:367–371CrossRefGoogle Scholar
  27. 27.
    Razdan TK, Harkar S, Kachroo V, Koul GL (1982) Phytolaccanol and epiacetylaleuritolic acid, two triterpenoids from Phytolacca acinosa. Phytochemistry 21:2339–2342CrossRefGoogle Scholar
  28. 28.
    Razdan TK, Harkar S, Kachroo V, Koul GL, Waight ES (1983) Triterpenoids from Phytolacca, three oleanane derivatives. Phytochemistry 22:1797–1800CrossRefGoogle Scholar
  29. 29.
    Harkar S, Razdan TK, Waight ES (1984) Further triterpenoids and carbon-13 NMR spectra of oleanane derivatives from Phytolacca acinosa. Phytochemistry 23:2893–2898CrossRefGoogle Scholar
  30. 30.
    Woo WS, Shin KH, Kang SS (1976) Constituents of Phytolacca species. I. Antiinflammatory saponins. Soul Taehakkyo Saengyak Yonguso Opjukjip 15:103–106 (CA 88:146072p)Google Scholar
  31. 31.
    Woo WS, Shin KH (1976) Antiinflammatory action of Phytolacca saponin. Soul Taehakkyo Saengyak Yonguso Opjukjip 15:90–96 (CA 88:69156g)Google Scholar
  32. 32.
    Liu FC, Ding GX, Li JX (1984) Effects of the total saponin from Phytolacca root on the incorporation 3H-thymidine into liver and spleen tissue. Chin Trad Herb Drugs 15:506–508Google Scholar
  33. 33.
    Ussery MA, Irvin JD, Hardesty B (1977) Inhibition of poliovirus replication by a plant antiviral peptide. Am NY Acad Sci 284:431–440CrossRefGoogle Scholar
  34. 34.
    Masuho Y, Kishida K, Hara T (1982) Targeting of the antiviral protein from Phytolacca americana with an antibody. Biochem Biophys Res Commun 105:462–469PubMedCrossRefGoogle Scholar
  35. 35.
    Ramakrishnan S, Houston LL (1984) Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: potentiation by chloroquine. Science 223:58–61PubMedCrossRefGoogle Scholar
  36. 36.
    Ramakrishnan S, Houston LL (1984) Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies. Cancer Res 44:201–208PubMedGoogle Scholar
  37. 37.
    Bjorn MJ, Larrick J, Piatak M, Wilson KJ (1984) Characterization of translational inhibitors from Phytolacca americana. Amino-terminal sequence determination and antibody-inhibitor conjugates. Biochim Biophys Acta 790:154–163PubMedCrossRefGoogle Scholar
  38. 38.
    Ramakrishnan S, Houston LL (1985) Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide-linked pokeweed antiviral protein-antibody conjugates from blood. Cancer Res 45:2031–2036PubMedGoogle Scholar
  39. 39.
    Lambert JM, Senter PD, Yau-Young A, Blattler WA, Goldmacher VS (1985) Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins. J Biol Chem 260:12035–12041PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

Personalised recommendations