Skip to main content

Trichosanthes kirilowii Maxim.

  • Chapter
Chinese Drugs of Plant Origin

Abstract

Trichosanthes kirilowii Maxim. (Cucurbitaceae) and several other Trichosanthes species are used in traditional Chinese medicine. The following items concerning Trichosanthes species are officially listed in the Chinese Pharmacopoeia:

  • Tianhuafen, Radix Trichosanthis, is the dry roots of T. kirilowii or T. japonica Regel collected in the fall and winter. It is used in traditional Chinese medicine as an antiphlogistic. It was also found to be effective as an abortifacient.

  • Gualou, Fructus Trichosanthis, is the dry ripe fruits of T. kirilowii or T. rosthornii Harms. The fruits are harvested in the fall when they have become ripe and are to be used as an antipyretic and expectorant, and in the treatment of constipation.

  • Gualouzi, Semen Trichosanthis, is the dry ripe seeds of T. kirilowii or T. rosthornii collected in the fall. They are used as an expectorant and in the treatment of constipation.

  • Gualoupi, Pericarpium Trichosanthis, is the dry pericarp of the ripe fruits of T. kirilowii or T. rosthornii, used as an expectorant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wang Y (1985) Chemistry of trichosanthin, a new biologically active plant protein. In: Chang HW, Yeung HW, Tso WW, Koo A (eds) Advances in Chinese Medicinal Research. World Science, Singapore, pp 289–293

    Google Scholar 

  2. Wang YH, Ling JF, Zhu LX (1976) Preliminary studies on an abortifacient plant protein, trichosanthin. Acta Zool Sin 22:137–143

    CAS  Google Scholar 

  3. Shanghai Institute of Organic Chemistry (1980) Chemistry of trichosanthin. In: Shen ZW (ed) Nucleic Acid Proteins. Science, Beijing, pp 318–323

    Google Scholar 

  4. Jin SW, Sun XX, Wang SF, Tian GY, Gu ZW, Qian WW, Liu YZ, She WY, Qian RQ, Wang Y (1981) Chemistry of trichosanthin. I. Physical and chemical properties of crystalline trichosanthin. Acta Chim Sin 39:917–925

    CAS  Google Scholar 

  5. Wang Y, Qian RQ, Gu ZW, Jin SW, Zhang LQ, Xia ZX, Tian GY, Ni CZ (1986) Scientific evaluation of Tian Hua Fen (THF) — history, chemistry and application. Pure Appl Chem 58:789–798

    Article  CAS  Google Scholar 

  6. Gu ZW, Zhang XL, Zhu AQ, Zhang WQ, Fu YH, Weng QX, Wu YW, Liu YF, et al. (1981) Chemistry of trichosanthin II. Determination of N-terminal partial amino acid sequence of trichosanthin. Acta Chim Sin 39:927–931

    Google Scholar 

  7. Gu ZW, Qian RQ, Jin SW, Qian WW, Xu SZ, Zhang LQ, Zhang XL, Yao YZ, Liu YF, et al. (1984) Chemistry of trichosanthin. IV. The principal primary structure of trichosanthin. Acta Chim Sin 42:943–945

    CAS  Google Scholar 

  8. Zhuang PQ, Gao XC, Zhang YM (1983) Secondary structure studies of trichosanthin by circular dichroism. Jiegou Huaxue 2:47–52

    CAS  Google Scholar 

  9. Zhuang PQ, Gao XC, Zhang YM (1983) Secondary structure estimation of trichosanthin by statistical analysis. Jiegou Huaxue 2:53–56

    CAS  Google Scholar 

  10. Wu TW, Pang KC, Wu CC, Wu HT, Chang YM, Ni CC, Chu SC (1978) Growth of single crystals and determination of unit-cell parameters for trichosanthin. Kexue Tongbao 23:176–178

    CAS  Google Scholar 

  11. Pan KZ, Zhang YM, Lin YZ, Wu CW, Zheng A, Chen YZ, Dong YC, Chen SZ, Wu S, Ma XQ, Wang YP, Zhang MA, Xia ZX, Tian GY, Fan ZC, Ni CZ, Ma YL, Sun XX (1985) The secondary structure of trichosanthin. In: Chang HM, Yeung HW, Tso WW, Koo A (eds) Advances in Chinese Medicinal Material Research. World Science, Singapore, pp 297–303

    Google Scholar 

  12. Fang YX, Zhu ZY, He DJ, Tian GY (1985) Chemistry of trichosanthin. VI. Determination of the secondary structure of trichosanthin by laser Raman spectroscopy. Acta Chim Sin 43:965–969

    CAS  Google Scholar 

  13. Pan KZ, Zhang YM, Lin YJ, Wu ZW, Zheng A, Chen YZ, Dong YC, Ma XQ, Wang YP, Wu S, Zhang MA, Chen SZ, Xia ZX, Tian GY, Ni CZ, Fan ZC, Ma YL, Sun XX (1985) The backbone structure of trichosanthin. In: Chang HM, Yeung HW, Tsa WW, Koo A (eds) Advances in Chinese Medicinal Material Research, World Science, Singapore, pp 305–309

    Google Scholar 

  14. Zhang XJ, Wang JH (1986) Homology of trichosanthin and ricin A chain. Nature 321:477–478

    PubMed  CAS  Google Scholar 

  15. Wang JH, Wang YP, Tian GY (1985) A new crystal form of trichosanthin. Kexue Tongbao [Foreign Lang] 30:1396–1398

    CAS  Google Scholar 

  16. Tan FL, Zhang GD, Mu JF, Lin NQ, Chi CW (1984) Purification, characterization and sequence determination of a double-headed trypsin inhibitor peptide from Trichosanthes kirilowii (a Chinese medical herb). Hoppe Seylers Z Physiol Chem 365:1211–1217

    Article  PubMed  CAS  Google Scholar 

  17. Tian GY, Li ST, Tang TB, Wang DC (1985) Trichosanthes polysaccharide. I. Isolation and physical and chemical properties. Acta Biochim Biophys Sin 17:582–586

    CAS  Google Scholar 

  18. Chang MC, Saksena SK, Lau IF, Wang YH (1979) Induction of mid-term abortion by trichosanthin in laboratory animals. Contraception 19:175–184

    Article  PubMed  CAS  Google Scholar 

  19. Lau IF, Sakana SK, Chang MC (1980) Further studies on the trichosanthin-induced termination of pregnancy. Contraception 21:77–86

    Article  PubMed  CAS  Google Scholar 

  20. Zhou MH, Li Q, Shu HD, Bao YM, Chu YH (1982) Pharmacological study of the effect of Radix Trichosanthis on terminating early pregnancy. Acta Pharm Sin 17:176–181

    CAS  Google Scholar 

  21. Saksena SK, Chang MC, Lau IF (1979) Termination of pregnancy in rabbit and mouse by trichosanthin. Contraception 20:367–376

    Article  PubMed  CAS  Google Scholar 

  22. Jiang TJ, Gao KX, Zhou GZ, Zhu YP, Cai HP (1977) Changes in urinary pregnanediol and estriol excretions during second trimester abortion induced by trichosanthin — a protein from Radix Trichosanthis. Acta Zool Sin 23:243–254

    CAS  Google Scholar 

  23. Wang YF, Wen D, Liu JX, Fi C, Zhu WX, Chen YZ, Yu Z, Yan LM, Shen GS (1981) Prostaglandin E and F levels in plasma and amniotic fluid during mid-trimester abortion induced by trichosanthin. Prostaglandins 22:289–294

    Article  PubMed  CAS  Google Scholar 

  24. Chu YH, Zhao ZF (1985) Effect of trichosanthin on progesterone, progesterone receptor and prostaglandin F2a level in pregnant rat uteri. Acta Pharm Sin 20:262–266

    CAS  Google Scholar 

  25. Saksena SK, Lau IF (1980) Effects of prostaglandin F2a and a plant protein “trichosanthin”, on 10-day pregnant rabbits. Prostaglandins Med 5:383–390

    Article  PubMed  CAS  Google Scholar 

  26. Wu RS, Zhang SM, Ma JW (1985) Rat model of passive lung anaphylaxis induced by trichosanthin. Acta Pharmacol Sin 6:68–71

    CAS  Google Scholar 

  27. Jin YC (1985) Clinical study of trichosanthin. In: Chang HM, Yeung MW, Tso WW, Koo A (eds) Advances in Chinese Medicinal Material Research. World Science, Singapore, pp 319–326

    Google Scholar 

  28. Liu FY, Chen SY, Li YJ, Liu GW, Zhou ZR, Lu CL, Zhao ML (1986) Allergic reaction to trichosanthin assays of serum IgE and specific anti-trichosanthin IgE levels. Chin J Obst Gynecol 21:165–167

    CAS  Google Scholar 

  29. Liu GW, Liu FY, Li YJ, Yu SH (1985) A summary of 402 cases of termination of early pregnancy with crystalline preparations of trichosanthins. In: Chang HM, Yeung HW, Tso WW, Koo A (eds) Advances in Chinese Medicinal Material Research. World Science, Singapore, pp 327–333

    Google Scholar 

  30. Gu H, Ye M, Yao Z (1986) Preparation, isolation and characterization of mouse IgE monoclonal antibodies against trichosanthin protein. Acta Biol Exper Sin 19:109–119

    CAS  Google Scholar 

  31. Gu H, Ye M, Yao Z (1986) Investigation of antigenic determinants on trichosanthin by antibody competitive binding assay. Acta Biol Exper Sin 19:121–129

    CAS  Google Scholar 

  32. Ji YY, Jiang ZQ, Ye M (1986) The production of monoclonal antiidiotypic antibodies against trichosanthin-specific IgE by rat-mouse hybridomas. Acta Biol Exper Sin 19:91–98

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tang, W., Eisenbrand, G. (1992). Trichosanthes kirilowii Maxim.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_118

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73739-8_118

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73741-1

  • Online ISBN: 978-3-642-73739-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics