Skip to main content

Positronenemissionstomographie in der Differentialdiagnostik und Therapiekontrolle dementieller Erkrankungen

  • Conference paper
Dementielle Erkrankungen
  • 45 Accesses

Zusammenfassung

Die Entwicklung computergesteuerter tomographischer Darstellungsmethoden hat die Medizintechnik des letzten Jahrzehntes entscheidend geprägt. Mit Einführung der axialen Röntgencomputertomographie (CT) 1973 durch Hounsfield wurde es in der zerebralen Diagnostik möglich, anatomische Strukturen durch Dichteunterschiede des Gewebes dreidimensional sichtbar zu machen und pathologische Prozesse abzugrenzen, soweit sie die Röntgenabsorption des Gewebes verändern [23]. Die Darstellung physiologischer und biochemischer Parameter ist mittels cranialem CT nicht möglich. Dies gilt mit Einschränkung auch für die Magnetresonanztomographie (MRT), die morphologische Strukturen mit hohem räumlichen Auflösungsvermögen erfaßt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alavi A, Fazekas F, Chawluk J, Zimmerman R (1987) Magnetic resonance imaging of the brain in normal aging and dementia. In: Meyer JS, Lechner H, Reivich M, Ott EO (eds) Cerebral Vascular Disease 6. Excerpta Medica, Amsterdam New York Oxford, pp 191–195

    Google Scholar 

  2. Baxter LR, Phelps ME, Mazziotta JC et al. (1987) Local cerebral glucose metabolic rates in obsessive-compulsive disorder - a comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiat 44: 211–218

    Article  PubMed  Google Scholar 

  3. Chase TN, Fedio P, Foster NL et al. (1984) Wechsler adult intelligence scale performance - cortical localization by fluorodeoxyglucose F18-posi- tron emission tomography. Arch Neurol 41: 1244–1247

    Article  PubMed  CAS  Google Scholar 

  4. Coyle JT, Price DL, Delong MR (1983) Alzheimer’s disease: A disorder of cortical cholinergic innervation. Science 219: 1184–1190

    Article  PubMed  CAS  Google Scholar 

  5. DeLeon MJ, Ferris SH, George AE et al. (1983) Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer’s disease. J Cereb Blood Flow Metab 3: 391–394

    Article  PubMed  Google Scholar 

  6. Duara R, Grady C, Haxby J et al. (1984) Human brain glucose utilization and cognitive function in relation to age. Ann Neurol 16: 702–713

    Article  CAS  Google Scholar 

  7. Duara R, Grady C, Haxby J et al. (1986) Positron emission tomography in Alzheimer’s disease. Neurology 36: 879–887

    PubMed  CAS  Google Scholar 

  8. Eriksson L, Bohm C, Kesselberg M et al. (1982) A four ring positron camera system for emission tomography of the brain. IEEE Trans Nucl Si 29: 539–543

    Article  Google Scholar 

  9. Ferris SH, Reisberg B, Crook T et al. (1982) Pharmacologic treatment of senile dementia: Choline, L-dopa, piracetam, and choline plus piracetam. In: Corkin S et al. (eds) Alzheimer’s Disease: A Report of Progress. Raven Press, New York, pp 475–481

    Google Scholar 

  10. Foster NL, Chase TN, Fedio P et al. (1983) Alzheimer’s disease: focal cortical changes shown by positron emission tomography. Neurology (Cleveland) 33: 961–965

    CAS  Google Scholar 

  11. Foster NL, Chase TN, Patronas NJ et al. (1986) Cerebral mapping of apraxia in Alzheimer’s disease by positron emission tomography. Ann Neurol 19: 139–143

    Article  PubMed  CAS  Google Scholar 

  12. Frackowiak RSJ, Pozzilli C, Legg NJ et al. (1981) Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 104: 753–778

    Article  PubMed  CAS  Google Scholar 

  13. Friedland RP, Budinger TF, Ganz E et al. (1983) Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with (18F)fluorodeoxyglucose. J Comput Assist Tomogr 7: 590–598

    Article  PubMed  CAS  Google Scholar 

  14. Gibbs JM, Frackowiak RSJ, Legg NJ (1986) Regional cerebral blood flow and oxygen metabolism in dementia due to vascular disease. Gerontology 32 (Suppl 1): 84–88

    Article  PubMed  Google Scholar 

  15. Hachinski VC, Iliff LD, Zilkha E et al. (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632–637

    Article  PubMed  CAS  Google Scholar 

  16. Haxby JV, Duara R, Grady CL et al. (1985) Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer’s disease. J Cereb Blood Flow Metab 5: 193–200

    Article  PubMed  CAS  Google Scholar 

  17. Haxby JV, Grady CL, Duara R et al. (1986) Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s type dementia. Arch Neurol 43: 882–885

    Article  PubMed  CAS  Google Scholar 

  18. Haxby JV, Grady CL, Koss E et al. (1987) Longitudinal study of brain metabolic and neuropsychological heterogeneity in dementia of the Alzheimer type: evidence for subtypes. J Cereb Blood Flow Metab 7 (Suppl 1): S377

    Google Scholar 

  19. Hayden MR, Hewitt J, Stoessl AJ et al. (1987) The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of Huntington’s disease. Neurology 37: 1441–1447

    PubMed  CAS  Google Scholar 

  20. Heiss WD, Pawlik G, Herholz K et al. (1984) Regional kinetic constants and CMRGlu in normal human volunteers determined by dynamic positron emission tomography of (18F)-2-fluoro-2-deoxy-D-glucose. J Cereb Blood Flow Metab 4: 212–223

    Article  PubMed  CAS  Google Scholar 

  21. Heiss WD, Herholz K, Bôcher-Schwarz HG et al. (1986) PET, CT, and MR imaging in cerebrovascular disease. J Comput Assist Tomogr 10: 903–911

    Article  PubMed  CAS  Google Scholar 

  22. Horwitz B, Duara R, Rapoport SI (1986) Age differences in inter-correla- tions between regional cerebral metabolic rates for glucose. Ann Neurol 19: 60–67

    Article  PubMed  CAS  Google Scholar 

  23. Hounsfield GN (1973) Computerized transverse axial scanning (tomography). I. Description of system. Brit J Radiol 46: 1016–1022

    Article  PubMed  CAS  Google Scholar 

  24. Jamieson DG, Chawluk JB, Alavi A et al. (1987) The effect of disease severity on local cerebral glucose metabolism in Alzheimer’s disease. J Cereb Blood Flow Metab 7 (Suppl 1): S410

    Google Scholar 

  25. Kamo H, McGeer PL, Harrop R et al. (1987) Positron emission tomography and histopathology in Pick’s disease. Neurology 37: 439–445

    PubMed  CAS  Google Scholar 

  26. Kuhl DE, Metter EJ, Riege WH, Phelps ME (1982) Effects of human aging on patterns of local cerebral glucose utilization determined by the (18F)fluorodeoxyglucose method. J Cereb Blood Flow Metab 2: 163–171

    Article  PubMed  CAS  Google Scholar 

  27. Kuhl DE, Metter EJ, Riege WH et al. (1983) Local cerebral glucose utilization in elderly patients with depression, multiple infarct dementia, and Alzheimer’s disease. J Cereb Blood Flow Metab 3 (Suppl 1): S494–S495

    Google Scholar 

  28. Kuhl DE, Metter EJ, Riege WH, Markham CH (1984) Patterns of cerebral glucose utilization in Parkinson’s disease and Huntington’s disease. Ann Neurol 15 (Suppl): S119–S125

    Article  PubMed  Google Scholar 

  29. Kuhl DE, Small GW, Riege WH et al. (1987) Cerebral metabolic patterns before the diagnosis of probable Alzheimer’s disease. J Cereb Blood Flow Metab 7 (Suppl 1): 406

    Google Scholar 

  30. Mazziotta JC, Phelps ME, Carson RE, Kuhl DE (1982) Tomographic mapping of human cerebral metabolism: Sensory deprivation. Ann Neurol 12: 435–444

    Article  PubMed  CAS  Google Scholar 

  31. Mazziotta JC, Phelps ME, Pahl JJ et al. (1987) Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington’s disease. New Engl J Med 316: 357–362

    Article  PubMed  CAS  Google Scholar 

  32. Phelps ME, Huang SC, Hoffman EJ et al. (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2- fluoro-2-deoxy-D-glucose: Validation of method. Ann Neurol 6: 371–388

    Article  PubMed  CAS  Google Scholar 

  33. Reivich M, Kuhl D, Wolf A et al. (1979) The (18F)fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137

    PubMed  CAS  Google Scholar 

  34. Rossor MN, Emson PC, Mount joy CQ et al. (1982) Neurotransmitters of the cerebral cortex in senile dementia of Alzheimer type. Exp Brain Res Suppl 5: 153–157

    Article  CAS  Google Scholar 

  35. Sokoloff L, Reivich M, Kennedy C et al. (1977) The (14C)-deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897–916

    Article  PubMed  CAS  Google Scholar 

  36. Summers WK, Majovski LV, Marsh GM et al. (1986) Oral tetrahydroami- noacridine in long-term treatment of senile dementia, Alzheimer-type. New Engl J Med 315: 1241–1245

    Article  PubMed  Google Scholar 

  37. Szelies B, Karenberg A (1986) Störungen des Glukosestoffwechsels bei Pick’scher Erkrankung. Fortschr Neurol Psychiat 54: 393–397

    Article  PubMed  CAS  Google Scholar 

  38. Szelies B, Herholz K, Pawlik G et al. (1986) Zerebraler Glukosestoffwechsel bei präseniler Demenz vom Alzheimer-Typ - Verlaufskontrolle unter Therapie mit muskarinergem Cholinagonisten -. Fortschr Neurol Psychiat 54: 364–373

    Article  PubMed  CAS  Google Scholar 

  39. Ter-Pogossian MM, Phelps ME, Hoffman EJ, Mullani NA (1975) A positron-emission transaxial tomograph for nuclear imaging ( PETT ). Radiology 114: 89–98

    PubMed  CAS  Google Scholar 

  40. Terry RD, Peck A, De Teresa R et al. (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10: 184–192

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Szelies, B., Herholz, K., Pawlik, G., Heiss, WD. (1988). Positronenemissionstomographie in der Differentialdiagnostik und Therapiekontrolle dementieller Erkrankungen. In: Weitbrecht, WU. (eds) Dementielle Erkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73738-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73738-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19307-4

  • Online ISBN: 978-3-642-73738-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics