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Breast Cancer Risk and Chemoprevention

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High-Risk Breast Cancer

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Abstract

The purpose of this chapter is to discuss the potential role of retinoids in breast cancer chemoprevention. Chemoprevention may be defined as the use of natural substances and their synthetic analogs or of other chemicals to reduce the likelihood of cancer development. For epithelial cancers, which account for the majority of human malignancies, chemoprevention consists of intervention measures taken during the development of the neoplastic process up to the stage of in situ carcinoma. Excellent reviews [8, 32, 50] have discussed this topic since the concept and the term were introduced a decade ago [73]. However, the question of dose of chemopreventive agents in relation to the stages of tumor formation has not been adequately addressed. This issue will be specifically considered from a clinical perspective based on an overview of experimental, epidemiologic, and clinical evidence.

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References

  1. Alfthan O, Tarkkanen J, Grohn P, Heinonen E, Pyrhonen S, Saila K (1983) Tigason (etretinate) in prevention of recurrence of superficial bladder tumors. A double-blind clinical trial. Eur Urol 9: 6–9

    PubMed  CAS  Google Scholar 

  2. Anderson DE (1974) Genetic study of breast cancer: identification of a high risk group. Cancer 34: 1090–1097

    Article  PubMed  CAS  Google Scholar 

  3. Band PR, Besner JG, Leclaire R, Girard C, Diorio G, Deschamps M, Gelinas M, Larochelle D (1982) Phase I study of 13-cis-retinoic acid toxicity. Cancer Treat Rep 66: 1759–1761

    PubMed  CAS  Google Scholar 

  4. Band PR, Deschamps M, Falardeau M, Ladouceur J, Coté J (1984) Treatment of benign breast disease with vitamin A. Prev Med 13: 549–554

    Article  PubMed  CAS  Google Scholar 

  5. Berenblum I (1982) Sequential aspects of chemical carcinogenesis: skin. In: Becker FF (ed) Cancer, vol 1. Plenum, New York, pp 451–484

    Google Scholar 

  6. Bollag W (1972) Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid). Eur J Cancer 8: 689–693

    Article  PubMed  CAS  Google Scholar 

  7. Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10: 731–737

    Article  PubMed  CAS  Google Scholar 

  8. Bollag W (1983) Vitamin A and retinoids: from nutrition to pharmacotherapy in dermatology and oncology. Lancet i: 860–863

    Article  Google Scholar 

  9. Boyd NF, O’Sullivan B, Campbell JE, Fishell E, Simon I, Cooke G, Germanson T (1982) Mammographic signs as risk factors for breast cancer. Br J Cancer 45: 185–193

    Article  PubMed  CAS  Google Scholar 

  10. Breitman TR, Selonick SE, Collins SJ (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 77: 2936–2940

    Article  PubMed  CAS  Google Scholar 

  11. Brisson J, Merletti F, Sandowsky NL, Twaddle JA, Morrison AS, Cole P (1982) Mammographie features of the breast and breast cancer risk. Am J Epidemiol 115: 428–437

    PubMed  CAS  Google Scholar 

  12. Chatterjee M, Banerjee MR (1982) Influence of hormones on N-(4-hydroxyphenyl)- retinamide inhibition of 7,12-dimethylbenz(a)anthracene transformation of mammary cells in organ culture. Cancer Lett 16: 239–245

    Article  PubMed  CAS  Google Scholar 

  13. Clavel F, Benhamou E, Sitruk-Ware R, Mauvais-Jarvis P, Flamant R (1985) Breast cancer and oral contraceptive: a review. Contraception 6: 553–569

    Article  Google Scholar 

  14. Cohen SM, Wittenberg JF, Bryan GT (1976) Effect of avitaminosis A and hyper- vitaminosis A on urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide. Cancer Res 36: 2334–2339

    PubMed  CAS  Google Scholar 

  15. Consensus meeting (1986) Is “fibrocystic disease” of the breast precancerous. Arch Pathol Lab Med 110: 171–173

    Google Scholar 

  16. Crocker JJ, Sanders LL (1970) Influence of vitamin A and 3,7-dimethyl-2,6-octadienal (citral) on the effect of benzo(a)pyrene on the hamster trachea in organ culture. Cancer Res 30: 1312–1318.

    PubMed  CAS  Google Scholar 

  17. De Wys WD, Greenwald P (1983) Clinical trials: a recent emphasis in the prevention program of the National Cancer Institute. Semin Oncol 10: 360–364

    Google Scholar 

  18. deWaard F, Baanders-van Helewijn EA (1974) A prospective study in general practice on breast cancer risk in postmenopausal women. Int J Cancer 14: 153–160

    Article  PubMed  Google Scholar 

  19. Dickens MS, Custer RP, Sorof S (1979) Retinoid prevents mammary gland transformation by carcinogenic hydrocarbons in whole organ culture. Proc Natl Acad Sci USA 76: 5891–5895

    Article  PubMed  CAS  Google Scholar 

  20. Dion LD, Blalock JE, Gilford GE (1977) Vitamin A-induced density dependent inhibition of L-cell proliferation. J Natl Cancer Inst 58: 795–801

    PubMed  CAS  Google Scholar 

  21. Dion LD, Blalock JE, Gilford GE (1978) Retinoic acid and the restoration of anchorage dependent growth to transformed mammalian cells. Exp Cell Res 117: 15–22

    Article  PubMed  CAS  Google Scholar 

  22. Dupont WD, Page DL (1985) Risk factors for breast cancer in women with proliferative breast disease. New Engl J Med 312: 146–151

    Article  PubMed  CAS  Google Scholar 

  23. Dupont WD, Page DL (1987) Breast cancer risk associated with proliferative disease, age at first birth, and a family history of breast cancer. Am J Epidemiol 125: 769–779

    PubMed  CAS  Google Scholar 

  24. Farber E (1984) The multi-step nature of cancer development. Cancer Res 44: 4217– 4223

    PubMed  CAS  Google Scholar 

  25. Fraker LD, Halter SA, Forbes JT (1984) Growth inhibition by retinol of a human breast carcinoma cell line in vitro and in athymic mice. Cancer Res 44: 5757–5763

    PubMed  CAS  Google Scholar 

  26. Fujimaki Y (1926) Formation of gastric carcinoma in albino rats fed on deficient diets. J Cancer Res 10: 469–477

    Google Scholar 

  27. Gouveia J, Hercend T, Lemaigre G, Mathé G, Gros F, Santelli G, Homasson JP, Angebault M, Lededente A, Parrot R, Gaillard JP, Bonniot JP, Marsac J, Pretet S (1982) Degree of bronchial metaplasia in heavy smokers and its regression after treatment with a retinoid. Lancet i: 710–712

    Article  Google Scholar 

  28. Grubbs CJ, Moon RC, Sporn MB, Newton DL (1977) Inhibition of mammary cancer by retinyl methyl ether. Cancer Res 37: 599–602

    PubMed  CAS  Google Scholar 

  29. Hadjimichael OC, Boyle CA, Meigs JW (1986) Abortion before first live birth and risk of breast cancer. Br J Cancer 53: 281–284

    Article  PubMed  CAS  Google Scholar 

  30. Harisiadis L, Miller RC, Hall EJ, Borek C (1978) A vitamin A analogue inhibits radiation induced oncogenic transformation. Nature 274: 486–487

    Article  PubMed  CAS  Google Scholar 

  31. Henderson BC, Pike MC, Ross RK (1984) Epidemiology and risk factors. In: Bonadonna G (ed) Breast cancer: diagnosis and management. Wiley, Toronto, pp 15–33

    Google Scholar 

  32. Hill DL, Grubbs CJ (1982) Retinoids as chemopreventive and anticancer agents in intact animals (review). Anticancer Res 2: 111–124

    PubMed  CAS  Google Scholar 

  33. Hislop TG, Coldman AJ, Elwood JM, Skippen DH, Kan L (1986) Relationship between risk factors for breast cancer and hormonal status. Int J Epidemiol 15: 469–476

    Article  PubMed  CAS  Google Scholar 

  34. Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, Fofonoff S, Byers R, Atkinson EN, Vaughan C, Toth BB, Kramer A, Dimery IW, Skipper P, Strong S (1986) 13-cis-Retinoic acid in the treatment of oral leukoplakia. N Engl J Med 315: 1501–1546

    Article  PubMed  CAS  Google Scholar 

  35. Hryniuk W, Bush H (1984) The importance of dose intensity in chemotherapy of metastatic breast cancer. J Clin Oncol 2: 1281–1288

    PubMed  CAS  Google Scholar 

  36. Huber PR, Geyer E, Kung W, Matter A, Torhorst J, Eppenberger U (1978) Retinoic acid-binding protein in human breast cancer and dysplasia. J Natl Cancer Inst 61: 1375–1378

    PubMed  CAS  Google Scholar 

  37. Hutchinson WB, Thomas DB, Hamlin WB, Roth GJ, Peterson AV, Williams B (1980) Risk of breast cancer in women with benign disease. J Natl Cancer Inst 65: 13–20

    PubMed  CAS  Google Scholar 

  38. Jetten AR, Jetten MER (1979) Possible role of retinoic acid and binding protein in retinoid stimulation of embryonal carcinoma cell differentiation. Nature 278: 180–182

    Article  PubMed  CAS  Google Scholar 

  39. Kelsey JL, Hildreth NE (1983) Breast and gynecologic cancer epidemiology. CRC, Boca Raton, pp 5–50

    Google Scholar 

  40. Kerndrup G, Bendix-Hansen K, Pedersen B, Ellegaard J, Hokland P (1986) Primary myelodysplastic syndrome: treatment of 6 patients with 13-cis-retinoic acid. Scand J Haematol 36 (Suppl 45): 128–132

    Google Scholar 

  41. Koch HF (1978) Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid. J Maxillofac Surg 6: 59–63

    Article  PubMed  CAS  Google Scholar 

  42. Kolonel LN, Nomura AM, Hinds MW, HirohataT, Hankin JH, Lee J (1983) Role of diet in cancer incidence in Hawaii. Cancer Res 43: 2397s-2402s

    PubMed  CAS  Google Scholar 

  43. Kummet T, Moon TE, Meyskens FL (1983) Vitamin A: evidence for its preventive role in human cancer. Nutr Cancer 5: 96–106

    Article  PubMed  CAS  Google Scholar 

  44. Kung WM, Geyer E, Eppenberger U, Huber PR (1980) Quantitative estimation of cellular retinoic acid-binding protein activity in normal, dysplastic and neoplastic human breast tissue. Cancer Res 40: 4265–4269

    PubMed  CAS  Google Scholar 

  45. Lane BP, Miller SL (1976) Effects of vitamin A on carcinogen induced changes in tracheal epithelial organ cultures (Abstract). Proc Am Assoc Cancer Res 17: 211

    Google Scholar 

  46. Lasnitzki I (1955) The influence of A hypervitaminosis on the effect of 20-methyl- cholanthrene on mouse prostate glands grown in vitro. Br J Cancer 9: 434–441

    Article  PubMed  CAS  Google Scholar 

  47. Lasnitzki I (1962) Hypovitaminosis A in the mouse prostate gland cultured in defined medium. Exp Cell Res 28: 40–51

    Article  CAS  Google Scholar 

  48. Lasnitzki I (1976) Reversal of methylcholanthrene-induced changes in mouse prostates in vitro by retinoic acid and its analogues. Br J Cancer 34: 239–248

    Article  PubMed  CAS  Google Scholar 

  49. Leis HP (1978) Epidemiology of breast cancer: identification of high risk women. In: Gallagher HS, Lois HP, Snyderman RK, Urban JA (eds) The breast. Mosby, St Louis, pp 37–48

    Google Scholar 

  50. Lotan R (1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605: 33–91

    PubMed  CAS  Google Scholar 

  51. Macklin MT (1959) Comparison of the number of breast cancer deaths observed in relatives of breast cancer patients, and the number expected on the basis of mortality rate. J Natl Cancer Inst 22: 927–951

    PubMed  CAS  Google Scholar 

  52. MacMahon B, Feinleib M (1960) Breast cancer in relation to nursing and menopausal history. J Natl Cancer Inst 24: 733–753

    PubMed  CAS  Google Scholar 

  53. MacMahon B, Cole P, Brown J (1972) Etiology of human breast cancer: a review. J Natl Cancer Inst 50: 21–42

    Google Scholar 

  54. McCormick DL, Moon RC (1982) Influence of delayed administration of retinyl acetate on mammary carcinogenesis. Cancer Res 42: 2639–2643

    PubMed  CAS  Google Scholar 

  55. McCormick DL, Moon RC (1986) Retinoid-tamoxifen interaction in mammary cancer chemoprevention. Carcinogenesis 7: 193–196

    Article  PubMed  CAS  Google Scholar 

  56. McCormick DL, Burns FJ, Albert RE (1980) Inhibition of rat mammary carcinogenesis by short dietary exposure to retinyl acetate. Cancer Res 40: 1140–1143

    PubMed  CAS  Google Scholar 

  57. McCormick DL, Sowell ZL, Thompson CA, Moon RC (1983) Inhibition by retinoid and ovariectomy of additional malignancies in rats following surgical removal of the first mammary cancer. Cancer 51: 594–599

    Article  PubMed  CAS  Google Scholar 

  58. Mehta RG, Cerny WL, Moon RC (1983) Retinoids inhibit prolactin-induced development of the mammary gland in vitro. Carcinogenesis 4: 23–36

    Article  PubMed  CAS  Google Scholar 

  59. Merriman RL, Bertram JS (1979) Reversible inhibition by retinoids of 3-methylcholan- threne-induced neoplastic transformation in C3H/10T 1/2 clone 8 cells. Cancer Res 39: 1661–1666

    PubMed  CAS  Google Scholar 

  60. Miller AB (1986) Dietary fat and the epidemiology of breast cancer. Prog Clin Biol Res 222: 17–32

    PubMed  CAS  Google Scholar 

  61. Moon RC, Thompson HJ, Becci PJ, Grubbs CJ, Gander RJ, Newton DL, Smith JM, Phillips SL, Henderson WR, Mullen LT, Brown CC, Sporn MB (1979) N-(4- Hydroxyphenyl) retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res 39: 1339–1346

    PubMed  CAS  Google Scholar 

  62. Moskowitz M, Gartside P, Wirman JA, McLaughlin C (1980) Proliferative disorders of the breast as risk factors for breast cancer in a self-selected screened population: pathologic markers. Radiology 134: 289–291

    PubMed  CAS  Google Scholar 

  63. Munoz N, Bang LJ, Day NE, Yan WE, Yun ZC, Correa P, Wahrendorf J, Crespi M, Ji ZH, Lin LG, Fang ZS, O’Conor GT, Thurnham DI, Grassi A, Quan LY, Yao LJ, Bosch X (1985) No effect of riboflavine, retinol, and zinc on prevalence of precancerous lesions of oesophagus. Randomized double-blind intervention study in high risk population of China. Lancet ii: 111–114

    Article  Google Scholar 

  64. Nettesheim P, Snyder C, Kim JCS (1979) Vitamin A and the susceptibility of respiratory tract tissues to carcinogenic insult. Environ Health Perspect 29: 89–93

    Article  PubMed  CAS  Google Scholar 

  65. Page DL, Zanderswaag RV, Rogers LW, Williams LT, Walker WE, Hartmann WH (1978) Relation between component parts of fibrocystic disease complex and breast cancer. J Natl Cancer Inst 61: 1055–1063

    PubMed  CAS  Google Scholar 

  66. Page DL, Dupont WD, Rogers LW, Rados MS (1985) Atypical hyperplastic lesions of the female breast: a long-term follow-up study. Cancer 55: 2698–2708

    Article  PubMed  CAS  Google Scholar 

  67. Peck GL, Gross EG, Butkus D, DiGiovanna JJ (1982) Chemoprevention of basal cell carcinoma with isotretinoin. J Am Acad Dermatol 6: 815–823

    Article  PubMed  CAS  Google Scholar 

  68. Peto R, Doll R, Buckley JD, Sporn MB (1981) Can dietary β-carotene materially reduce human cancer rates? Nature 290: 201–208

    Article  PubMed  CAS  Google Scholar 

  69. Rogers AE, Herndon BJ, Newberne PM (1973) Vitamin A and dimethylhydrazine- induced colon carcinoma in the rat. Cancer Res 33: 1003–1009

    PubMed  CAS  Google Scholar 

  70. Saffiotti U, Montesano R, Sellakumar AR, Borg SA (1967) Experimental cancer of the lung. Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer 20: 857–864

    Article  PubMed  CAS  Google Scholar 

  71. Shroder EW, Black PH (1980) Retinoids: tumor preventers or tumor enhancers? J Natl Cancer Inst 65: 671–674

    Google Scholar 

  72. Sporn MB, Roberts AB (1983) Role of retinoids in differentiation and carcinogenesis. Cancer Res 43: 3034–3040

    PubMed  CAS  Google Scholar 

  73. Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs. Fed Proc 35: 1332–1338

    PubMed  CAS  Google Scholar 

  74. Sporn MB, Squire RA, Brown CC, Smith JM, Wenk ML, Springer S (1977) 13–cis- Retinoic acid: inhibition of bladder carcinogenesis in the rat. Science 195: 487–489

    Article  PubMed  CAS  Google Scholar 

  75. Strickland S, Sawey MJ (1980) Studies on the effect of retinoids on the differentiation of teratocarcinoma stem cells in vitro and in vivo. Dev Biol 78: 76–85

    Article  PubMed  CAS  Google Scholar 

  76. Tabar L, Dean PB (1982) Mammographic parenchymal patterns: risk indicator for breast cancer? JAMA 247: 185–189

    Article  PubMed  CAS  Google Scholar 

  77. Thomas DB, Chu J (1986) Nutritional and endocrine factors in reproductive organ cancers: opportunities for primary prevention. J Chronic Dis 39: 1031–1050

    Article  PubMed  CAS  Google Scholar 

  78. Thompson HJ, Becci PJ, Grubbs CJ, Shealy YF, Stanek EJ, Brown CC, Sporn MB, Moon RC (1981) Inhibition of urinary bladder cancer by N-(ethyl)-all-traws-retinamide and N-(2-hydroxyethyl)-all-trans-retinamide in rats and mice. Cancer Res 41: 933–936

    PubMed  CAS  Google Scholar 

  79. Thompson HJ, Meeker LD, Tagliaferro AR, Becci PJ (1982) Effect of retinyl acetate on the occurrence of ovarian hormone-responsive and -nonresponsive mammary cancers in the rat. Cancer Res 42: 903–905

    PubMed  CAS  Google Scholar 

  80. Threatt B, Norbeck JM, Ullman N, Kummer R, Roselle P (1980) Association between mammographic parenchymal pattern classification and incidence of breast cancer. Cancer 45: 2550–2556

    Article  PubMed  CAS  Google Scholar 

  81. Todaro GJ, De Larco JE, Sporn MB (1978) Retinoids block phenotypic cell transformation produced by sarcoma growth factor. Nature 276: 272–274

    Article  PubMed  CAS  Google Scholar 

  82. Tokuhata GK (1969) Morbidity and mortality among offspring of breast cancer mothers. Am J Epidemiol 89: 139–153

    PubMed  CAS  Google Scholar 

  83. Trapido EJ (1983) Age at first birth, parity and breast cancer risk. Cancer 51: 946–948

    Article  PubMed  CAS  Google Scholar 

  84. Trichopoulos D, MacMahon B, Cole P (1972) Menopause and breast cancer risk. J Natl Cancer Inst 48: 605–613

    PubMed  CAS  Google Scholar 

  85. Verma AK, Boutwell RK (1977) Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis. Cancer Res 37: 2196–2201

    PubMed  CAS  Google Scholar 

  86. Waterhouse J, Muir C, Correa P, Powell J (eds) (1976) Cancer incidence in five continents, vol 3. IARC, Lyon (IARC scientific publication no 15)

    Google Scholar 

  87. Weinstein IB, Yamasaki H, Wigler M, Lee L-S, Fisher PB, Jeffrey A, Grunberger D (1979) Molecular and cellular events associated with the action of initiating carcinogens and tumor promoters. In: Griffin AC, Shaw CR (eds) Carcinogens: identification and mechanisms. Raven, New York, pp 399–418

    Google Scholar 

  88. Wellings SR, Wolfe JN (1978) Correlative studies of the histological and radiologic appearance of the breast parenchyma. Radiology 129: 299–306

    PubMed  CAS  Google Scholar 

  89. Welsch CW, Brown CK, Goodrich-Smith M, Chiusano J, Moon RC (1980) Synergistic effect of chronic prolactin suppression and retinoid treatment in the prophylaxis of N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats. Cancer Res 40: 3095–3098

    PubMed  CAS  Google Scholar 

  90. Welsch CW, De Hoog JV, Scieszka KM, Aylsworth CF (1984) Retinoid feeding, hormone inhibition, and/or immune stimulation and the progression of N-methyl-N- nitrosourea-induced rat mammary carcinoma: suppression by retinoids of peptide hormone-induced tumor cell proliferation in vivo and in vitro. Cancer Res 44: 166–171

    PubMed  CAS  Google Scholar 

  91. Wetherall NT, Taylor CM (1986) The effects of retinoid treatment and antiestrogens on the growth of T47D human breast cancer cells. Eur J Cancer Clin Oncol 22: 53–59

    Article  PubMed  CAS  Google Scholar 

  92. Wolbach SB, Howe PR (1925) Tissue changes following deprivation of fat soluble A vitamin. J Exp Med 42: 753–777

    Article  PubMed  CAS  Google Scholar 

  93. Wolfe JN (1976) Risk for breast cancer development determined by mammographic parenchymal pattern. Cancer 37: 2486–2492

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Epidemiology, Biometry and Occupational Oncology, Cancer Control Agency of British Columbia, 600 West 10th Avenue, V5Z4E6, Vancouver, BC, Canada

    P. R. Band, A. J. Coldman & M. Deschamps

  2. National Health and Research Development Program, Health and Welfare, Canada

    M. Deschamps

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  1. P. R. Band
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  2. A. J. Coldman
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Editors and Affiliations

  1. Medical Oncology, Cancer Control Agency of British Columbia, 600 West 10th Avenue, Vancouver, B.C., V5Z 4E6, Canada

    Joseph Ragaz MD, FRCP

  2. Foundation for Clinical Research Inc., 80 East End Avenue, New York, NY, 10028, USA

    Irving M. Ariel MD

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Band, P.R., Coldman, A.J., Deschamps, M. (1989). Breast Cancer Risk and Chemoprevention. In: Ragaz, J., Ariel, I.M. (eds) High-Risk Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73718-3_2

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