Growth Regulation of Breast Cancer

  • D. Yee
  • M. E. Lippman


The normal proliferation of breast epithelium at the time of puberty is dependent on increasing ovarian estrogen concentrations. Breast cancers also appear to be regulated by estrogens. Approximately 60% of metastatic breast tumors express estrogen receptors (ERs), and 50% of these can be treated effectively with hormonal manipulation. Risk factors for breast cancer include early menarche, nulliparity, increased height or weight, and late menopause, all suggestive that prolonged estrogen exposure unopposed by progesterone may be important in breast cancer development [122].


Breast Cancer Breast Cancer Cell Human Breast Cancer Cell Human Breast Cancer Cell Line Dalton Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • D. Yee
    • 1
  • M. E. Lippman
    • 1
  1. 1.Medical Breast Cancer Section, Medicine Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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