Effects of Long-Term Administration of Sandostatin® (SMS 201–995) at Increasing Doses in 40 Acromegalic Patients. Results from the French Sandostatin Acromegaly Study Group
Several studies demonstrate the efficacy of short- and long-term Sandostatin® treatment in acromegaly administered subcutaneously at doses ranging from 150 to 300 µg up to 600 µg per day [1, 3, 5, 7–10]. A rhythm of 3 injections per day has been shown to reduce the magnitude of the re-elevation of growth hormone (GH) which occurs before the following injection when Sandostatin is given only twice daily. However, some patients fail to respond adequately to the above-mentioned doses thus pointing to the possible need for higher doses of Sandostatin  or continuous subcutaneous infusion.
KeywordsGrowth Hormone Pituitary Adenoma Acromegalic Patient Growth Hormone Concentration Tumor Size Reduction
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