Thermodynamics of Energy Conversion in the Cell
The aim of every evolved and adapted biological system should consist in extracting the quality of energy to do work, i.e. the exergy , from the available foodstuff in possibly the most efficient manner. This work may consist in muscular contraction, ion transport across a membrane, synthesis and assembly of the building blocks of the organism, etc. Common to all these processes is that they are driven by the energy-rich ATP. The most important source of ATP is oxidative phosphorylation which is localized within the mitochondria. In this process the exergy liberated from the combustion of reducing equivalents is converted into the formation of ATP. Therefore, oxidative phosphorylation can be considered as an exergetic energy converter. The aim of this paper is to give insight into some mechanisms by which the cell can optimize the exergetic efficiency of oxidative phosphorylation.
KeywordsEntropy Depression Creatine Crest Cond
Unable to display preview. Download preview PDF.
- 1.K.S. Spiegier: Principles of Energetics (Springer Verlag, Berlin, Heidelberg 1983)Google Scholar
- 2.P.W. Atkins: The Second Law (Scientific American Library, W.H. Freeman & Company, New York 1984)Google Scholar
- 5.J.J. Lemasters, W.H. Bulica: J. Biol. Chem. 256, 12949 (1981)Google Scholar
- 6.H.V. Westerhoff: Mosaic Nonequi 1ibri urn Thermodynamics, PhD Thesis, Amsterdam (Drukkerij Geria, Waarland 1983)Google Scholar
- 12.J.W. Stucki: in preparationGoogle Scholar
- 13.J.W. Stucki: In Metabolie Compartmentation, ed. by H. Sies (Academic Press, New York 1982) p. 39Google Scholar
- 15.L. Wojtzak: J. Bioenerg. Biomembr. 8, 293 (1976)Google Scholar
- 16.F. Wold: TIBS 11, 58 (1986)Google Scholar
- 22.A.L. Veuthey, J.W. Stucki: in preparationGoogle Scholar
- 23.G. Nicolis, I. Prigogine: Self-Organization in Noneguilibrium Systems (J. Wiley & Sons, New York 1977)Google Scholar
- 25.P.A. Samuelson: Economics (McGraw-Hill, International Student Edition 1981)Google Scholar