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Rökan pp 133-142 | Cite as

Mechanisms of Effect of Ginkgo Biloba Extract on Experimental Cerebral Edema

  • A. Etienne
  • F. Hecquet
  • F. Clostre
Conference paper

Summary

Oedema is one of the major complication of cerebral ischaemia being at the same time a consequence and an aggravating factor.Its firstphase is intracellular and cytotoxic, with breakdown of ionic pumps through loss of energy, resulting in a whole sequence of ionic pertubations characterized by loss of intracellular K+ and accumulation of water and Na+, Cl, and Ca2+ ions in the cells of the ischaemic zone.

The second phase, termed vasogenic, applies to the accumulation of lactates, inorganic phosphates and free polyunsaturated fatty acids and in particular, arachidonic acid. This last compound is responsible for the production of membrane “aggressors”, amongst which free radicals play an important role.

Ginkgo biloba extract limits the formation of cerebral oedema and suppresses its neurological consequences, whether the oedema is of cytotoxic (triethyltin) or vasogenic (unilateral traumatic oedema) origin. Several membrane mechanisms could be implicated in the protective action manifested by Ginkgo biloba extract against cerebral oedema.

Keywords

Arachidonic Acid Cerebral Ischaemia Cerebral Edema Cerebral Tissue Ginkgo Biloba Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baron J.C.: Phénomènes physiopathologiques au cours de l’ischémie focale aiguë du cerveau. Revue Méd., 1983, 38, 1853–1863.Google Scholar
  2. 2.
    Borzeix M.G., Labos M., Cahn J.: A propos d’un modèle expérimental d’oedème cérébral pour l’étude des substances agissant sur le débit sanguin et/ou le métabolisme cérébral. Agressologie, 1972, 13, 257–260.PubMedGoogle Scholar
  3. 3.
    Borzeix M.G., Weber S., Akimjak J.P.: Cerebral edema induced by triethyltin (TET) in the rabbit and in the rat. In: Proc. of the 7th International Congress of Pharmacology, Satellite Symposium of Reims, 1978.Google Scholar
  4. 4.
    Borzeix M.G.: Effect of Ginkgo biloba Extract on 2 types of cerebral edema. In: Effects of Ginkgo biloba Extract on Organic Cerebral Impairment, Agnoli A., Rapin J.R., Scapagnini V., Weitbrecht W.V., Eda, John Libbey, London, 1985, 51–56.Google Scholar
  5. 5.
    Braquet P., De Feudis F.V., Deby C., Braquet M.: Involvement of oxygen free radicals in biologic and pathologic processes. In: Cerebral Ischaemia, Bes A., Braquet P., Paoletti R., Siesjö B.K., Eds., Excerpta Medica, Amsterdam, 1984, 265–283.Google Scholar
  6. 6.
    Braquet P., Braquet M., Deby C.: Oxidative damages induced by cerebral ischemia: protective role of some radical scavengers and related drugs. J. Cerebral Blood Flow and Metabolism, 1983, 3, supl. 1, 564-565.Google Scholar
  7. 7.
    Chatterjee S.S., Gabard B.: Protective effect of an extract of Ginkgo biloba and other hydroxyl radical scavengers against hypoxia. Eighth International Congress of Pharmacology,1981, Tokyo, Abstract 866.Google Scholar
  8. 8.
    Chatterjee S.S.,: Effects of Ginkgo biloba Extract on metabolic processes. In: Effects of Ginkgo biloba Extract on Organic Cerebral Impahnient, Agnoli A., Rapin J.R., Scapagnini V., Weitbrecht W.V., Eds., John Libbey, London, 1985, 5–15.Google Scholar
  9. 9.
    Cohadon F.: Physiopathologie de l’oedème cérébral ischémique. Circulation et Métabolisme du Cerveau, 1983, 1, 45–54.Google Scholar
  10. 10.
    DeFeudis F.V., Auguet M., Delaflotte S., Hellegouarch A., Baranes J., Chapelat M., Braquet M., Etienne A., Drieu K., Clostre F., Braquet P.: Some in vitro and in vivo actions of an extract of Ginkgo biloba (GbE 761). In: Effects of Ginkgo biloba extract on Organic Cerebral Impairment, Agnoli A., Rapin J.R., Scapagnini V., Weitbrecht W.V., Eds. John Libbey, London, 1985, 17–29.Google Scholar
  11. 11.
    Doly M., Braquet P., Droy M.T., Bonhomme B., Vennat J.C.: Effets des radicaux libres oxygénés sur l’activité électrophysiologique de la rétine isolée de rat. J. Fr. Ophtalmol.,1985, 8.Google Scholar
  12. 12.
    Etienne A., Baranes J., Hecquet F., Hellegouarch A., Clostre F.: Effet stabilisateur de membrane d’un extrait de Ginkgo biloba. Planta Medica, 1980, 39, 327.Google Scholar
  13. 13.
    Etienne A., Chapelat M., Braquet M., Clostre F., Drieu K., DeFeudis F.V., Braquet P.: In vivo studies of free radical scavenging activity; relation to cerebral ischaemia. In: Cerebral Ischaemia, Bes A., Braquet P., Paoletti R., Siesjö B.K., Eds. Excerpta medica, Amsterdam, 1984, 379–384.Google Scholar
  14. 14.
    Etienne, A., Hacquet F., Clostre F., DeFeudis F.V.: Comparaison des effets d’un extrait de Ginkgo biloba et de la chlorpromazine sur la fragilité osmotique in vitro d’ érythrocytes de rat. J. Pharmacol., 1982, 13, 291–298.PubMedGoogle Scholar
  15. 15.
    Gabard B., Chatterjee S.S.: Cerebral edema induced by triethyltin in the rat: Effects of an extract of Ginkgo biloba. Naunym Schmiedeberg’s Arch. Pharmacol.,311, (suppl.) R 68.Google Scholar
  16. 16.
    Karchel I., Zagermann P., Krieglstein J.: Effect of an Extract of Ginkgo biloba on rat brain energy metabolism in hypoxia, Naunym Schmiedeberg’s Arch. Pharmacol., 1984, 327, 31–35.CrossRefGoogle Scholar
  17. 17.
    Kariman K.: Mecanisms of cell damage in brain ischemia: a hypothesis. Life Sciences, 1985, 37, 71–73.PubMedCrossRefGoogle Scholar
  18. 18.
    Kimelberg H.K.: Glial enzymes and ion transport in brain swelling. In:seminar in neurological surgery. In: Neural trauma, Pepp A.J., Bourke R.S., Melson L.R., Kimelbert M.K., Eds., Raven Press,137–155.Google Scholar
  19. 19.
    Le Poncin Lafitte M., Rapin J.R.: Effects of Ginkgo biloba on changes induced by quantitative cerebral micro-embolization in rats. Arch. Int. Pharmacodyn., 1980, 243, 236–244.Google Scholar
  20. 20.
    Marcy R.: Dossier d’AMM Tanakan, Rapport d’expertise pharmacologique, 1980.Google Scholar
  21. 21.
    Otani M., Chatterjee S.S., Gabard B., Kreutzberg G.W.: Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema. Acta Neuropathol., 1986, 69, 54–65.PubMedCrossRefGoogle Scholar
  22. 22.
    Overgaard, J.: Cerebral blood flow brain edema. Circulation et Métabolisme du cerveau, 1984, 2, 11–22.Google Scholar
  23. 23.
    Pickard J.D., Walker V.: Current concepts of the role of prostaglandins and other eicosanoïds in acute cerebrovascular disease. In:Lers vol., 2 Mackenzie E.T. ed., Raven Press,New York, 191–218.Google Scholar
  24. 24.
    Siesjö B.K.: Cell damage in the brain: A speculative synthesis. J. Cerebral Blood Flow and Metabolism, 1981, 1, 155–185.CrossRefGoogle Scholar
  25. 25.
    Spinnewyn B., Blavet N., Clostre F.: Effets du Ginkgo biloba sur l’ischémie cérébrale expérimentale chez la gerbille. Presse Méd., 1986, 15, 1511–1515.PubMedGoogle Scholar
  26. 26.
    Van Caneghen P.: Influence of some hydrosoluble substances with vitamin P activity on the fragility of lysosomes in vitro. Biochem. Pharm., 1972, 21, 1543–1548.Google Scholar
  27. 27.
    Williams T.J., Jose P.J., Wedmore C.V., Peck M.J., Forrest M.J.: Mechanisme underlying inflammatory oedoma: The importance of synergism prostaglandins, leukotrienes and complement derived peptides. In:Advances in Prostaglandin, Thromboxane, and Leukotriene Research, vol. 11, Samuelsson B., Paoletti R., Ramwell P. Eds., Raven Press,New York, 33–37.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 1988

Authors and Affiliations

  • A. Etienne
    • 1
  • F. Hecquet
    • 1
  • F. Clostre
    • 1
  1. 1.Centre de recherche I.H.B.-I.P.S.E.N.Les UlisFrance

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