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Mechanisms of Effect of Ginkgo Biloba Extract on Experimental Cerebral Edema

  • A. Etienne
  • F. Hecquet
  • F. Clostre
Conference paper


Oedema is one of the major complication of cerebral ischaemia being at the same time a consequence and an aggravating factor.Its firstphase is intracellular and cytotoxic, with breakdown of ionic pumps through loss of energy, resulting in a whole sequence of ionic pertubations characterized by loss of intracellular K+ and accumulation of water and Na+, Cl, and Ca2+ ions in the cells of the ischaemic zone.

The second phase, termed vasogenic, applies to the accumulation of lactates, inorganic phosphates and free polyunsaturated fatty acids and in particular, arachidonic acid. This last compound is responsible for the production of membrane “aggressors”, amongst which free radicals play an important role.

Ginkgo biloba extract limits the formation of cerebral oedema and suppresses its neurological consequences, whether the oedema is of cytotoxic (triethyltin) or vasogenic (unilateral traumatic oedema) origin. Several membrane mechanisms could be implicated in the protective action manifested by Ginkgo biloba extract against cerebral oedema.


Arachidonic Acid Cerebral Ischaemia Cerebral Edema Cerebral Tissue Ginkgo Biloba Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg New York 1988

Authors and Affiliations

  • A. Etienne
    • 1
  • F. Hecquet
    • 1
  • F. Clostre
    • 1
  1. 1.Centre de recherche I.H.B.-I.P.S.E.N.Les UlisFrance

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