Alterations in Cell Surface Carbohydrates Affecting Invasion in Vitro

  • D. C. C. Schallier
  • J. G. M. Bolscher
  • L. A. Smets

Abstract

Cell surface carbohydrates, mainly associated with glycolipids and integral membrane glycoproteins, can cover the entire cell surface. By consequence, they form the first layer of interaction between cells and contribute significantly to the chemical, immunological and “lectinological” identity of the cell (reviewed in Berger et al., 1982; Montreuil, 1983; Smets and Van Beek, 1984; Hakomori, 1984).

Keywords

Sugar Filtration Carbohydrate Leukemia Recombination 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berger EG, Buddecke E, Kamerling JP, Kobata A, Paulson JC, Vliegenthart JFG (1982) Structure, biosynthesis and function of glycoprotein glycans. Experientia 38: 1129–1258PubMedCrossRefGoogle Scholar
  2. Bolscher JGM, Schallier DCC, Smets LA, Van Rooy H, Collard JG, Bruyneel EA, Mareel MMK (1986) Effect of cancer-related and drug-induced alterations in surface carbohydrates on the invasive capacity of mouse and rat cells. Cancer Res 46: 4080–4086PubMedGoogle Scholar
  3. Bolscher JGM, Schallier DCC, Van Rooy H, Storme GA, Smets LA (1988) Modification of cell surface carbohydrates and invasion by an alkyl-lysophospholipid. Cancer Res 48:in pressGoogle Scholar
  4. Bolscher JGM, Van der Bijl M, Hall A, Smets LA, Ploegh HL (1988) Altered protein glycosylation: an early event after induction of increased or mutated p2lras expression. SubmittedGoogle Scholar
  5. Bracke ME, Van Cauwenberge, RML, Mareel MM (1984)(+)-Catechin inhibits the invasion of malignant fibrosarcoma cells into chick heart in vitro. Clin Exp Metastasis 2: 161–170PubMedCrossRefGoogle Scholar
  6. Brackenbury R (1985) Molecular mechanisms of cell adhesion in normal and transformed cells. Cancer Metastasis Rev 4: 41–58PubMedCrossRefGoogle Scholar
  7. Collard JG, Van Beek WP, Janssen JWG, Schijven JF (1985) Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer 35: 207–214PubMedCrossRefGoogle Scholar
  8. Collard JG, Schijven JF, Bikker A, La Riviere G, Bolscher JGM, Roos E (1986) Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas. Cancer Res 46: 3521–3527PubMedGoogle Scholar
  9. Dennis JW, Laferte S (1987) Tumor cell surface carbohydrate and the metastatic phenotype. Cancer Metastasis Rev 5: 185–204PubMedCrossRefGoogle Scholar
  10. Hakomori S (1984) Tumor-associated carbohydrate antigens. Ann Rev Immunol 2: 103–126CrossRefGoogle Scholar
  11. Mareel M, Kint J, Meyvisch C (1979) Methods of study of the invasion of malignant C3H-mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch. B Cell Pathol 30: 95–111Google Scholar
  12. Montreuil J, Debray H, Debeire P, Delannoy P (1983) Lectins as oligosaccharide receptors. In: Popper H, Reutter W, Gudat F, Kottgen E (eds) Structural carbohydrates in the liver. pp. 239–258. Mtp Press Limited BostonGoogle Scholar
  13. Nicolson GL (1984) Cell surface molecules and tumor metastasis. Exp Cell Res 150: 3–22PubMedCrossRefGoogle Scholar
  14. Pinsker MC, Mintz B (1973) Changes in cell-surface glycoproteins of mouse embryos before implantation. Proc Nat]. Acad Sci USA 70: 1645–1648Google Scholar
  15. Rothbard JB, Brackenbury R, Cunningham BA, Edelman GM (1982) Differences in the carbohydrate structures of neural cell adhesion molecules from adult and embryonic chicken brains. J Biol Chem 257: 11064–11069PubMedGoogle Scholar
  16. Schirrmacher V, Altevogt P, Fogel M, Dennis J, Waller CA, Barz D, Schwart R, Cheingsong-Popov R, Springer G, Robinson PJ, Nebe T, Brossmer W, Vlodaysky I, Paweletz N, Zimmermann HP and Uhlenbruck G (1982) Importance of cell surface carbohydrates in cancer cell adhesion, invasion and metastasis. Does sialic acid direct metastatic behavior? Invasion Metastasis 2: 313–360Google Scholar
  17. Smets LA (1980) Cell transformation as a model for tumor induction and neoplastic growth. Biochim Biophys Acta 605: 93–111PubMedGoogle Scholar
  18. Smets LA, Van Beek WP (1984) Carbohydrates of the tumor cell surface. Biochim Biophys Acta 738: 237–249PubMedGoogle Scholar
  19. Steinberg MS (1975)Adhesion-guided multicellular assembly: a commentary upon the postulates, real and imagined, of the differential adhesion hypothesis, with special attention to computer simulation of cell sorting.J Theor Biol 55: 431–443PubMedCrossRefGoogle Scholar
  20. Takasaki S, Ikehira H, Kobata A (1980)Increase of asparaginelinked oligosaccharides with branched outer chains caused by cell transformation. Biochem Biophys Res Commun 92: 735–742PubMedCrossRefGoogle Scholar
  21. Van Beek WP, Smets LA, Emmelot P (1973) Increased sialic acid density in surface glycoproteins of transformed and malignant cells–a general phenomenon? Cancer Res 33: 2913–2922PubMedGoogle Scholar
  22. Van Beek WP, Smets LA, Emmelot P (1979) Tumor associated changes in the carbohydrate moiety of membrane glycoproteins. In: Boelsma E, Rumke P (eds) Tumour markers: Impact and Prospects. pp 61–78. Elsevier/North-Holland Biomedical Press AmsterdamGoogle Scholar
  23. Van Beek WP, Breekveldt J, De Bakker E, Hilgers J, Hilgers F, Nilsson K (1981) Early changes in the glycopeptides of human B-lymphocytes after Epstein-Barr virus infection in vitro. Int J Cancer 27: 23–28PubMedCrossRefGoogle Scholar
  24. Van Beek WP, Tulp A, Bolscher J, Blanken G, Roozendaal K Egbers M (1984) Transient versus permanent expression of cancer-related glycopeptides on normal versus leukemicmyeloid cells coinciding with marrow egress.Blood 63: 170–176PubMedGoogle Scholar
  25. Warren L, Buck CA, Tuszynski GP (1979) Glycopeptides changes and malignant transformation: a possible role for carbohydrate in malignant behavior. Biochim Biophys Acta 516: 97–127Google Scholar
  26. Warren L, Buck CA (1980) The membrane glycoproteins of the malignant cell. Clin Biochem 13: 191–197PubMedCrossRefGoogle Scholar
  27. Yamashita K, Tachibana Y, Ohkura T, Kobata A (1985) Enzymatic basis for the structural changes of asparagine-linked sugar chains of membrane glycoproteins of baby hamster kidney cells induced by polyoma transformation. J Biol Chem 260: 3963–3969PubMedGoogle Scholar
  28. Yogeeswaran G (1983) Cell surface glycolipids and glycoproteins in malignant transformation. Adv Cancer Res 38: 289–350PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. C. C. Schallier
    • 1
  • J. G. M. Bolscher
    • 2
  • L. A. Smets
    • 2
  1. 1.Oncologic CenterAcademic Hospital Free University BrusselsBrusselsBelgium
  2. 2.Division of Cellular BiochemistryThe Netherlands Cancer InstituteAmsterdamThe Netherlands

Personalised recommendations