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Effect of Beta-Lactam Antibiotics on Eukaryotic DNA Replication: Possible Impact on the Host-Parasite Relationship

  • Conference paper
The Influence of Antibiotics on the Host-Parasite Relationship III

Abstract

According to Waksman, antibiotics are substances produced by microorganisms which exhibit either an inhibitory or destructive effect on other microorganisms. That therapeutically effective concentrations of such products can be tolerated by humans and animals relates primarily to their highly specific interaction with well-defined target structures or functions of the microorganisms attacked which the human or animal cell lack. A prominent example of this is the functioning of the β-lactam antibiotics (BLAs). They specifically bind to and inhibit a number of enzymes involved in bacterial cell wall synthesis, the penicillin-binding proteins, thereby initiating the deleterious effects on growing bacteria [29].

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Author information

Authors and Affiliations

  1. Medical Clinic, University Hospital, Rämistr. 100, 8091, Zürich, Switzerland

    K. A. Neftel

  2. Institute of Pharmacology and Biochemistry University Zürich-Irchel, Winterthurer Str. 190, 8057, Zürich, Switzerland

    U. D. Huynh & U. Hübscher

Authors
  1. K. A. Neftel
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  2. U. D. Huynh
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  3. U. Hübscher
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Medizinischen Fakultät der RWTH Aachen, Pauwelsstrasse, D-5100, Aachen, Germany

    Günther Gillissen

  2. Abteilung für Theoretische und Klinische Medizin Lehrstuhl für Medizinische Mikrobiologie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630, Bochum, Germany

    Wolfgang Opferkuch

  3. Hygiene-Institut der Universität zu Köln, Goldenfelsstrasse 19-21, D-5000, Köln 41, Germany

    Georg Peters  & Gerhard Pulverer  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Neftel, K.A., Huynh, U.D., Hübscher, U. (1989). Effect of Beta-Lactam Antibiotics on Eukaryotic DNA Replication: Possible Impact on the Host-Parasite Relationship. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_37

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  • DOI: https://doi.org/10.1007/978-3-642-73653-7_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73655-1

  • Online ISBN: 978-3-642-73653-7

  • eBook Packages: Springer Book Archive

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