Antibiotics and the Host-Parasite Relationship in Cystic Fibrosis
Patients with cystic fibrosis (CF) have repeated pulmonary infections which lead to chronic bronchiectasis and other forms of lung damage. Although the causative gene has now been located on chromosome 7, and DNA sequences of that gene are being analysed, the reason for the recurrent respiratory infection is not known. Treatment with high doses of appropriate antibiotics, often for several weeks or even on a long-term basis, plays a most important part in management. However, despite newer antibiotics and, in particular, agents with much greater activity against Pseudomonas aeruginosa, many patients with antibiotic-sensitive bacteria in the sputum continue to suffer progressive lung damage.
KeywordsPseudomonas Ampicillin Prednisolone Lysozyme Staphylococcus
Unable to display preview. Download preview PDF.
- 3.Graft DF, Mischler)E et al. (1982) Granulocyte chemiluminescence in adolescent patients with cystic fibrosis. Amer Rev Respir Dis 125:540–543Google Scholar
- 4.Kowolik M, Raeburn JA, Grant M (1982) In vivo effect of ampicillin and cefaclor on blood and gingival crevicular neutrophil myeloperoxidase activity. In: Eichenberg H, Opferkuch W (eds) The influence of antibiotics on the host-parasite relationship. Springer, Berlin Heidelberg New York, pp 56–66CrossRefGoogle Scholar
- 7.Raeburn JA, McCrae WM (1976) Immune responses to bacteria in cystic fibrosis. Proceedings of the 7th international congress of cystic fibrosis. Paris, pp 541–544Google Scholar