Antibiotics and the Host-Parasite Relationship in Cystic Fibrosis
Patients with cystic fibrosis (CF) have repeated pulmonary infections which lead to chronic bronchiectasis and other forms of lung damage. Although the causative gene has now been located on chromosome 7, and DNA sequences of that gene are being analysed, the reason for the recurrent respiratory infection is not known. Treatment with high doses of appropriate antibiotics, often for several weeks or even on a long-term basis, plays a most important part in management. However, despite newer antibiotics and, in particular, agents with much greater activity against Pseudomonas aeruginosa, many patients with antibiotic-sensitive bacteria in the sputum continue to suffer progressive lung damage.
KeywordsCystic Fibrosis Recurrent Respiratory Infection Total Leucocyte Count Lung Damage Chemiluminescence Response
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