Abstract
The cephalosporin antibiotics continue to be further developed and are among the more popular agents for treating bacterial infections [14, 15]. It has been shown that certain cephalosporins, even in therapeutic concentrations, can suppress [3H]-thymidine incorporation by human peripheral blood lymphocytes following stimulation with mitogens or specific antigens [4, 8, 10]. Potential clinical implications for such observations remain unclear, since there is no assurance that such in vitro phenomena are paralleled by in vivo events. Studies designed to evaluate immune responses in animals, after injection with cephalosporins, have produced somewhat conflicting results [3, 5, 13], but do support the hypothesis that these agents may have immunoregulatory activity.
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Chaperon, E.A., Stonnington, A.C. (1989). Effects of Beta-Lactam Antibiotics on the Lymphocyte Responses In Vitro and in Animals. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_23
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DOI: https://doi.org/10.1007/978-3-642-73653-7_23
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