Traditional Chinese Medicines and Drugs in Relation to the Host-Defense Mechanism
Pseudomonas aeruginosa infection is observed mostly under immunosuppressive conditions. We have clarified that the combined use of antibiotics and specific antibodies is effective against mouse P. aeruginosa infection in vivo [1–5]. From our previous experiments, traditional Chinese medicines and crude drugs are known to cause stimulation of the reticuloendothelial system . Kiger et al.  found that P. aeruginosa treatment (108 killed organisms) had a capacity to induce release of tumor-necrotizing factor in the serum of bacille Calmette-Guérin (BCG)-pretreated mice to the same extent as lipopolysaccharide (LPS) treatment. Our experiments on tumor necrosis factor (TNF) have demonstrated the production of TNF as well as its associated severe toxicity [8–10]. Recently, recombinant human TNF has been mass produced and many actions of this factor have become clear. We have found that by employing traditional Chinese medicines as priming agents, the toxic symptoms after administration of LPS could be reduced.
KeywordsToxicity Glutathione Superoxide Polysaccharide Trypsin
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