Autosomal Dominant Ichthyosis Vulgaris

  • Heiko Traupe


Alibert [1] is credited with the first description of autosomal dominant ichthyosis vulgaris (ADI) under the designation “ichthyose nacrée.“ Peukert [14] noted the frequent familial occurrence of the disease and concluded that it was inherited as a dominant trait. A number of reports in the older literature mention that ADI seems frequently to skip a generation [13]. The skipping of a generation is typical for X-linked recessive inheritance, and in a number of families in which skipping of ichthyosis vulgaris is mentioned in the literature the disease may in fact have been X-linked recessive ichthyosis (XRI). The clinical and genetic features of ADI could be fully appreciated only after XRI had been delineated by Wells and Kerr [20, 21].


Atopic Dermatitis Stratum Corneum Granular Layer Keratin Filament Keratosis Follicularis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Heiko Traupe
    • 1
  1. 1.Department of Human GeneticsUniversity of NijmegenHB NijmegenThe Netherlands

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