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A Phylogenetic Hypothesis for Alzheimer’s Disease

  • Conference paper
Genetics and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Summary

It is proposed that Alzheimer’s disease is a human phylogenetic disease because of evidence that paired helical filaments, characteristic of the postmortem Alzheimer brain, are not found in brains of nonhuman primates; because of functional studies in life, and pathological studies postmortem, that the association neocortices and their connections are specifically involved throughout the course of the disease; and because of evidence that genes on chromosome 21 contribute to Alzheimer pathology in some families as well as in Down’s syndrome. It is argued that the association necortices and their connections, which underwent integrated elaboration during recent hominid evolution, became vulnerable to Alzheimer pathology through the genomic processes that promoted their evolution. Some genes involved in integrated phylogeny of the association system, therefore, may contribute to the genetic liability for Alzheimer’s disease in man.

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  1. S. I. Rapoport
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Editors and Affiliations

  1. Laboratoire de Biochimie Génétique, Hôpital Necker, 149 rue de Sèvres, 75014, Paris, France

    Pierre Marie Sinet

  2. INSERM U 161, 2 rue d’Alesia, 75014, Paris, France

    Yvon Lamour

  3. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, 75737, Paris Cédex, France

    Yves Christen

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Rapoport, S.I. (1988). A Phylogenetic Hypothesis for Alzheimer’s Disease. In: Sinet, P.M., Lamour, Y., Christen, Y. (eds) Genetics and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73647-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-73647-6_7

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