Genetic Linkage Studies in Late-Onset Alzheimer’s Disease Families
Alzheimer’s disease (AD) is a devastating neurological disorder and the leading cause of dementia among the elderly. Recent studies have localized the gene for familial AD to chromosome 21 in a series of early-onset AD families (EOAD; mean age-of-onset, < 60). Familial late-onset AD (LOAD; mean age-of-onset, > 60) is a more common clinical form of the disorder. Linkage studies undertaken to test the localization of LOAD families to chromosome 21 failed to establish linkage and excluded linkage from a portion of the region where the EOAD gene was localized. These findings suggest that more than one etiology may exist for familial Alzheimer’s disease and indicate the need for continued screening of the genome in LOAD families.
KeywordsDepression EDTA Recombination Agarose Dementia
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