A Multicapillary Distributed Model of Blood-Bone Exchange to Analyse Multiple Tracer Outflow Dilution Data
Multiple tracer outflow dilution (MTOD) experiments have been performed in our laboratories to study such exchange in which 125I-labelled albumin reference and 85Sr (Ca analogue), 86Rb (K analogue) diffusible tracers were injected together into Krebs-Ringer bicarbonate buffer which was infused through the tibial nutrient artery at a physiological rate of 2 ml/min; outflow samples were taken simultaneously every 5 s from the ipsilateral femoral vein over a period of 5 min (McCarthy and Hughes 1986).
KeywordsPermeability Albumin Bicarbonate Convolution Kelly
Unable to display preview. Download preview PDF.
- Bassingthwaighte JB, Goresky CA (1984) Modelling in the analysis of solute and water exchange in the microvasculature. In: Handbook of physiology. Renkin EH, Michel CC (eds) the cardiovascular system. IV. American Physiological Society, Bethesda, pp 549–626Google Scholar
- Lopez-Curto JA, Bassingthwaighte JB, Kelly PJ (1980) Anatomy of the micro vasculature of the tibial diaphysis of the adult dog. J Bone Joint Surg [Am] 62A:1362–1369Google Scholar
- Willans SM (1987) Modelling in the analysis of ion exchange between blood and bone. PhD thesis, University of EdinburghGoogle Scholar