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A Multicapillary Distributed Model of Blood-Bone Exchange to Analyse Multiple Tracer Outflow Dilution Data

  • S. M. Willans
  • S. P. F. Hughes
  • I. D. McCarthy
Conference paper

Abstract

Multiple tracer outflow dilution (MTOD) experiments have been performed in our laboratories to study such exchange in which 125I-labelled albumin reference and 85Sr (Ca analogue), 86Rb (K analogue) diffusible tracers were injected together into Krebs-Ringer bicarbonate buffer which was infused through the tibial nutrient artery at a physiological rate of 2 ml/min; outflow samples were taken simultaneously every 5 s from the ipsilateral femoral vein over a period of 5 min (McCarthy and Hughes 1986).

Keywords

Diffusible Tracer Capillary System Final Parameter Estimate Outflow Sample Include Flow Rate 
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References

  1. Bassingthwaighte JB, Goresky CA (1984) Modelling in the analysis of solute and water exchange in the microvasculature. In: Handbook of physiology. Renkin EH, Michel CC (eds) the cardiovascular system. IV. American Physiological Society, Bethesda, pp 549–626Google Scholar
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  6. Tothill P, Hooper G, McCarthy ID, Hughes SPF (1987) The pattern of distribution of blood flow in dog limb bones measured using microspheres. Clin Phys Physiol Meas 8:239–248PubMedCrossRefGoogle Scholar
  7. Willans SM, McCarthy ID (1986) Distributed model of blood-bone exchange. J Biomed Eng 8:235–243PubMedCrossRefGoogle Scholar
  8. Willans SM (1987) Modelling in the analysis of ion exchange between blood and bone. PhD thesis, University of EdinburghGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. M. Willans
  • S. P. F. Hughes
  • I. D. McCarthy

There are no affiliations available

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