A Multicapillary Distributed Model of Blood-Bone Exchange to Analyse Multiple Tracer Outflow Dilution Data

  • S. M. Willans
  • S. P. F. Hughes
  • I. D. McCarthy
Conference paper


Multiple tracer outflow dilution (MTOD) experiments have been performed in our laboratories to study such exchange in which 125I-labelled albumin reference and 85Sr (Ca analogue), 86Rb (K analogue) diffusible tracers were injected together into Krebs-Ringer bicarbonate buffer which was infused through the tibial nutrient artery at a physiological rate of 2 ml/min; outflow samples were taken simultaneously every 5 s from the ipsilateral femoral vein over a period of 5 min (McCarthy and Hughes 1986).


Diffusible Tracer Capillary System Final Parameter Estimate Outflow Sample Include Flow Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bassingthwaighte JB, Goresky CA (1984) Modelling in the analysis of solute and water exchange in the microvasculature. In: Handbook of physiology. Renkin EH, Michel CC (eds) the cardiovascular system. IV. American Physiological Society, Bethesda, pp 549–626Google Scholar
  2. Kelly PJ, Bassingthwaighte JB (1977) Studies on bone ion exchanges using multiple-tracer indicator-dilution techniques. Fed Proc 36(12):2634–2639PubMedGoogle Scholar
  3. Kuikka J, Levin M, Bassingthwaighte JB (1986) Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. Am J Physiol 250:H29–H42PubMedGoogle Scholar
  4. Lopez-Curto JA, Bassingthwaighte JB, Kelly PJ (1980) Anatomy of the micro vasculature of the tibial diaphysis of the adult dog. J Bone Joint Surg [Am] 62A:1362–1369Google Scholar
  5. McCarthy ID, Hughes SPF (1986) Inhibition of bone cell metabolism increases strontium-85 uptake. Calcif Tissue Int 39:386–389PubMedCrossRefGoogle Scholar
  6. Tothill P, Hooper G, McCarthy ID, Hughes SPF (1987) The pattern of distribution of blood flow in dog limb bones measured using microspheres. Clin Phys Physiol Meas 8:239–248PubMedCrossRefGoogle Scholar
  7. Willans SM, McCarthy ID (1986) Distributed model of blood-bone exchange. J Biomed Eng 8:235–243PubMedCrossRefGoogle Scholar
  8. Willans SM (1987) Modelling in the analysis of ion exchange between blood and bone. PhD thesis, University of EdinburghGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. M. Willans
  • S. P. F. Hughes
  • I. D. McCarthy

There are no affiliations available

Personalised recommendations