Bone Demineralization and Increased Bone Blood Flow in the Rat
Increased bone remodeling associated with hypervascularized hyperplastic bone marrow is observed in many clinical descriptions such as plasmocytoma, hyperparathyroïdism, Paget’s disease, metastatic carcinoma, thalassemia etc. Owing to the difficulty of the measurement of bone blood flow in human beings, we explored experimental models of rapid bone loss in Sprague-Dawley rats. Bone plasma flow (BPF), calcium content of bone and accretion rate were measured in paraplegia, sciatic nerve section, ovariectomy, orchidectomy, arthritis and deprivation of calcium and vitamin D.
KeywordsAccretion Rate Bone Demineralization Rapid Bone Loss Paraplegic Patient Marrow Adipose Tissue
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