Abstract
Acute leukemia consists of the proliferation of immature undifferentiated blast cells of the bone marrow. It is a heterogeneous disease. Approximately 85% of leukemias in childhood are acute lymphoblastic leukemias (ALL), 12% are acute myelocytic leukemias, and 3% are chronic myelocytic leukemias. In childhood, ALL shows many similarities to non-Hodgkin’s lymphoma (NHL), and cytologically no difference can be seen between ALL and NHL. By definition, the diagnosis of ALL is made when the proportion of blast cells in the bone marrow smear is 20% or higher and that of NHL when blast cells constitute less than 20%.
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References
Burchenal JA (1968) Long-term survivors in acute leukemia and Burkitt’s tumor. Cancer 21:595–599
Faber S, Diamond LK, Mercer RD, Sylvester RF, Wolff JA (1948) Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic · acid (aminopterin). New Engl J Med 238:787–791
Henze G, Langermann HJ, Fengler R et al. (1982) Therapiestudie BFM 79/81 zur Behandlung der akuten lymphoblastischen Leukamie bei Kindern und Jugendlichen: intensivierte Reinduktionstherapie für Patientengruppen mit unterschiedlichem Rezi-divrisiko. Klin Pädiat 194:195–203
Kornhuber B, Gerein V (1984) Transfusion-transmitted CMV infections. Clinical importance and means of prevention. Vox Sanguinis 46:396–398
Pinkel D (1971) Five-year follow up of “total therapy” of childhood lymphocytic leukemia. J Am Med Ass 216:648
Riehm H, Gadner H, Henze G, Kornhuber B, Langermann H, Müller-Weihrich S, Schellong G (1985) Acute lymphoblastic leukemia: Treatment results in three BFM studies (1970-1981). In: Veronesi U, Polli E, Bonadonna G, Santoro A, Emanuelli H (eds) Leucemia e linfoni — Diagnosi e therapia. Casa Editrici Ambrosiana, Milan
Riehm H, Gadner H, Henze G, Langermann HJ, Odenwald E (1980) The Berlin childhood acute lymphoblastic leukemia study. J Pediatr Hematol Oncol 2:299
Riehm H, Reiter A, Schrappe M, Berthold F, Dopfer R, Gerein V, Ludwig R, Ritter J, Stollmann B, Henze G (1986) Die corticosteroid-abhängige Dezimierung der Leukä-mie-Zellzahl im Blut als Prognosefaktor bei der ALL im Kindesalter (ALL-BFM 83). Klin Pädiat 199:151–160
Schrappe M, Beck J, Brandeis WE, Feickert H-J, Gadner H, Graf N, Havers W, Henze G, Jobke A, Kornhuber B, Kühl J, Lampert F, Müller-Weihrich St, Niethammer D, Reiter A, Rister M, Ritter J, Schellong G, Tausch W, Weinel P, Riehm H (1987) Die Behandlung der akuten lymphoblastischen Leukämie im Kindes- und Jugendalter: Ergebnisse der multizentrischen Therapiestudie ALL-BFM 81. Klin Pädiat 199:133–150
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© 1989 Springer-Verlag Berlin Heidelberg
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Kornhuber, B. (1989). Advances in the Chemotherapeutic Treatment of Childhood Leukemia. In: Drahovsky, D., Kornhuber, B. (eds) Human Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73642-1_6
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DOI: https://doi.org/10.1007/978-3-642-73642-1_6
Publisher Name: Springer, Berlin, Heidelberg
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