Advertisement

Immunopathogenic Mechanisms in Experimental Myocarditis: Evidence for Autoimmunity to the Virus Receptor and Antigenic Mimicry between the Virus and Cardiocyte

  • S. A. Huber
  • K. Simpson
  • A. Weller
  • M. Herzum

Abstract

The past 2 decades have witnessed remarkable advances in the understanding of the pathogenesis of myocarditis and dilated cardiomyopathy. Animal models of picornavirus-induced heart disease have helped to elucidate many of the factors involved in disease susceptibility and cardiac injury although much remains to be learned. The disease process can basically be divided into three distinct phases: viral infection, inflammation, and fibrosis in dilated cardiomyopathy.

Keywords

Dilate Cardiomyopathy Virus Receptor Coxsackie Virus Normal Mouse Serum Antigenic Mimicry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bowels NE, Dubowitz V, Sewry CA, Archard LC (1987) Dermatomyositis, polymyositis and coxsackie B virus infection. Lancet I: 1004–1007CrossRefGoogle Scholar
  2. 2.
    Crowell RL, Landau BJ (1970) Picornaviridae: enteroviruses-coxsackieviruses. In: Hsuing GD, Green RH (eds) CRC handbook series in clinical laboratory science, virology and rickettsiology, vol 1, part 1. CRC, Ft Lauderdale, pp 135–155Google Scholar
  3. 3.
    Crowell RL, Landau BJ (1983) Receptors in the initiation of picornavirus infections. In: H. Fraenkel-Conrat, Wagner RR (eds) Comprehensive virology, vol 18. Plenum, New York, pp 1–42Google Scholar
  4. 4.
    Estrin M, Smith C, Huber S (1987) Coxsackievirus B3 myocarditis: autoimmunity is L3T4+ T helper cell and IL-2 independent in BALB/c mice. Am J Pathol 127: 335–341PubMedGoogle Scholar
  5. 5.
    Gauntt CJ, Gomez PT, Duffey PS, Grant JA, Trent DW, Witherspoon SM, Paque RE (1984) Characterization and myocarditic capabilities of coxsackievirus B3 variants in selected murine strains. J Virol 52: 598–605PubMedGoogle Scholar
  6. 6.
    Godeny EK, Gauntt CJ (1987) In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis. Am J Pathol 129: 267–276PubMedGoogle Scholar
  7. 7.
    Herskowitz A, Wolfgram LJ, Rose NR, Beisel KW (1987) Coxsackievirus B3 murine myocarditis-marked strain differences in histopathologic features of early and late phase myocarditis. J Am Coll Cardiol 9: 1311–1319PubMedCrossRefGoogle Scholar
  8. 8.
    Huber SA, Job LP, Auld KP (1982) Influence of sex hormones on coxsackie B3 virus infection in BALB/c mice. Cell Immunol 67: 173–189PubMedCrossRefGoogle Scholar
  9. 9.
    Huber SA, Job LP (1983) Cellular immune mechanisms in coxsackievirus group B, type 3 induced myocarditis in BALB/c mice. Adv Exp Med Biol 161: 491–507PubMedGoogle Scholar
  10. 10.
    Huber SA, Lodge PA (1984) Coxsackievirus B3 myocarditis in BALB/c mice: evidence for autoimmunity to myocyte antigens. Am J Pathol 116: 21–29PubMedGoogle Scholar
  11. 11.
    Huber SA, Lodge PA (1986) Coxsackievirus B3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and BALB/c mice. Am J Pathol 122: 284–291PubMedGoogle Scholar
  12. 12.
    Huber SA, Lodge PA, Herzum M, Estrin M, Olszewski J (1987) The role of T lymphocytes in the pathogenesis of coxsackievirus B3 myocarditis. In: Kawai C, Abelmann WH, Matsumori A (eds) Pathogenesis of myocarditis and cardiomyopathy. Cardiomyopathy update 1. University of Tokyo Press, Tokyo, pp 9–21Google Scholar
  13. 13.
    Kandolf R, Ameis D, Kirschner P, Canu A, Hofschneider PH (1987) In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease. Proc Natl Acad Sci USA 84: 6272–6276PubMedCrossRefGoogle Scholar
  14. 14.
    Kishimoto C, Kuribayashi K, Masuda T, Tomioka N, Kawai C (1985) Experimental and immunological studies in viral myocarditis and dilated cardiomyopathy: significance of T lymphocytes in the severity of myocarditis. In: Sekiguchi M, Olsen EGJ, Goodwin JF (eds) Myocarditis and related disorders. Springer, Berlin Heidelberg New York, pp 218–220Google Scholar
  15. 15.
    Kishimoto C, Kuribayashi F, Fuhuma K, Masuda T, Tomiska N, Abelmann WH, Kawai C (1987) Immunologic identification of lymphocyte subsets in experimental murine myocarditis with encephalomyocarditic virus. Circ Res 61: 715–725PubMedGoogle Scholar
  16. 16.
    Kishimoto C, Misaki T, Crumpacker CS, Abelmann WH (1988) Serial immunologic identification of lymphocyte subsets in murine coxsackievirus B3 myocarditis: different kinetics and significance of lymphocyte subsets in the heart and peripheral blood. Circulation 77: 645–653PubMedCrossRefGoogle Scholar
  17. 17.
    Lerner AM, Reyes MP (1985) Coxsackievirus myocarditis — with special reference to acute and chronic effects. Prog Cardiovasc Dis 27: 374–394Google Scholar
  18. 18.
    Lodge PA, Herzum M, Huber SA (1987) Coxsackievirus B3 induced myocarditis: acute and chronic forms of the disease. Am J Pathol 128: 455–463PubMedGoogle Scholar
  19. 19.
    Lutton CW, Gudvangen RJ, Nealon TJ, Paque RE, Gauntt CJ (1985) Cellular immune responses in mice challenged with an a myocarditic variant of coxsackievirus B3. J Med Virol 17: 345–357PubMedCrossRefGoogle Scholar
  20. 20.
    Lyden DC, Huber SA (1984) Aggravation of coxsackievirus, group B, type 3-induced myocarditis and increase in cellular immunity to myocarditis and increase incellular immunity to myocyte antigens inpregnant BALB/c mice and animals treated with progesterone. Cell Immunol 87: 462–472PubMedCrossRefGoogle Scholar
  21. 21.
    Lyden DC, Feran M, Olszewski J, Job LP, Huber SA (1987) Coxsackievirus B3 induced myocarditis: effect of sex steroids on viremia and infectivity of cardiocytes. Am J Pathol 126:432–438PubMedGoogle Scholar
  22. 22.
    Matteucci D, Paglianti M, Giangregori AM, Capobianchi MR, Dianzani F, Bendinelli M (1985) Group B coxsackieviruses readily establish persistent infections in human lymphoid cell lines. J Virol 56: 651–654PubMedGoogle Scholar
  23. 23.
    Neu N, Beisel KW, Traystman MD, Rose NR, Craig SW (1987) Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to coxsackievirus B3 induced myocarditis. J Immunol 138: 2488–2492PubMedGoogle Scholar
  24. 24.
    Notkins AL, Onodera T, Prabhakar B (1984) Virus-induced autoimmunity. In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis. Springer, Berlin Heidelberg New York, pp 210–215CrossRefGoogle Scholar
  25. 25.
    Reagan KJ, Goldberg B, Crowell RL (1984) Altered receptor specificity of coxsackievirus B3 after growth in rhabdomyosarcoma cells. J Virol 49: 635–640PubMedGoogle Scholar
  26. 26.
    Reyes MP, Ho KL, Smith F, Lerner AM (1981) A mouse model of dilated-type cardiomyopathy due to coxsackievirus B3. J Infect Dis 144: 232–236PubMedCrossRefGoogle Scholar
  27. 27.
    Rose NR, Beisel KW, Herskowitz A, Neu N, Wolfgram LJ, Alvare FL, Traystman MD, Craig SW (1987) Cardiac myosin and auto immune myocarditis. In: Evered D, Whelan S (eds) Autoimmunity and autoimmune disease. Ciba Foundation Symposium 129. Wiley, Chichester 129: 3–24Google Scholar
  28. 28.
    Saegusa J, Prabhaker BS, Essani K, McClintock PR, Fukuda Y, Ferrans VJ, Notkins AL (1986) Monoclonal antibody to coxsackievirus B4 reacts with myocardium. J Infect Dis 153: 372–373PubMedCrossRefGoogle Scholar
  29. 29.
    Van de Rijn I, Zabriskie JB, McCarty M (1977) Group A streptoccal antigens cross-reactive with myocardium: purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen. J Exp Med 146: 579–599PubMedCrossRefGoogle Scholar
  30. 30.
    Wolfgram LJ, Beisel KW, Herskowitz A, Rose NR (1986) Variations in the susceptibility to coxsackievirus B3-induced myocarditis among different strains of mice. J Immunol 136: 1846–1852PubMedGoogle Scholar
  31. 31.
    Woodruff JF, Woodruff JJ (1974) Involvement of T lymphocytes in the pathogenesis of coxsackievirus B3 heart disease. J Immunol 133: 1726Google Scholar
  32. 32.
    Woodruff JF, Wong CY, Woodruff JJ (1977) Cytotoxic T cells in coxsackieviral disease. In: Weksler ME, Litwin SO, Riggio RR, Siskind GW (eds) Immune effector mechanisms in disease. Grune and Stratton, New York, pp 207–237Google Scholar
  33. 33.
    Woodruff JF (1980) Viral myocarditis: a review. Am J Pathol 101: 425–484PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. A. Huber
    • 1
  • K. Simpson
    • 1
  • A. Weller
    • 1
  • M. Herzum
    • 2
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA
  2. 2.Medizinische KlinikUniversität WürzburgWürzburgGermany

Personalised recommendations