Immunopathogenic Mechanisms in Experimental Myocarditis: Evidence for Autoimmunity to the Virus Receptor and Antigenic Mimicry between the Virus and Cardiocyte

  • S. A. Huber
  • K. Simpson
  • A. Weller
  • M. Herzum


The past 2 decades have witnessed remarkable advances in the understanding of the pathogenesis of myocarditis and dilated cardiomyopathy. Animal models of picornavirus-induced heart disease have helped to elucidate many of the factors involved in disease susceptibility and cardiac injury although much remains to be learned. The disease process can basically be divided into three distinct phases: viral infection, inflammation, and fibrosis in dilated cardiomyopathy.


Dilate Cardiomyopathy Virus Receptor Coxsackie Virus Normal Mouse Serum Antigenic Mimicry 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. A. Huber
    • 1
  • K. Simpson
    • 1
  • A. Weller
    • 1
  • M. Herzum
    • 2
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA
  2. 2.Medizinische KlinikUniversität WürzburgWürzburgGermany

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