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Virus-Induced Autoimmunity: Cross-Reactivity of Antiviral Antibodies with Self-Components

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New Concepts in Viral Heart Disease

Abstract

There are a number of important human diseases that have an autoimmune component. In some of these diseases, the autoimmune response is very broad, with autoantibodies present against a number of tissues and organs. For example, in systemic lupus erythematosus, autoantibodies against DNA, RNA, cytoplasmic proteins, lymphocytes, and erythrocytes are often found. Similarly, patients with polyendocrinopathy have autoantibodies to pancreas, thyroid, pituitary, and gastric mucosa. In contrast, patients with myasthenia gravis show a far more restricted autoimmune component with the predominant response directed against the acetylcholine receptor.

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Author information

Authors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, 20892, Bethesda, MD, USA

    B. S. Prabhakar, J. Srinivasappa & A. L. Notkins

  2. Department of Pathology and Microbiology, University of Nebraska Medical Center Omaha, 68105, NE, USA

    K. W. Beisel

Authors
  1. B. S. Prabhakar
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  2. J. Srinivasappa
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  3. K. W. Beisel
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  4. A. L. Notkins
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Editor information

Editors and Affiliations

  1. Med. Klinik I, Klinikum Großhadern, Marchioninistraße 15, 8000, München 70, Germany

    Heinz-Peter Schultheiß

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© 1988 Springer-Verlag Berlin Heidelberg

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Prabhakar, B.S., Srinivasappa, J., Beisel, K.W., Notkins, A.L. (1988). Virus-Induced Autoimmunity: Cross-Reactivity of Antiviral Antibodies with Self-Components. In: Schultheiß, HP. (eds) New Concepts in Viral Heart Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73610-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-73610-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73612-4

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