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Relapse-Reducing Effects of Acarbose After Weight Reduction in Severely Obese Subjects

  • L. Sjöström
  • T. William-Olsson
Conference paper

Abstract

The aim of this study (published in 1985) was to investigate whether acarbose has a relapse-preventing effect after body-weight reductions. Twenty-four obese subjects weighing on average 116 kg showed a mean weight loss of 28 kg during conventional caloric restriction. When a new, steady weight level had been achieved, the subjects were randomized to group A or B, in a double-blind, crossover design. Group A obtained 1500 mg acarbose per day for 1 year. The daily drug intake was divided into doses of 200–500 mg, given with each meal or snack. After a 2-week period without medication, placebo was then given for a 2nd year. In group B the acarbose-placebo sequence was reversed.

Keywords

Compute Tomography Diabetes Mellitus Laboratory Test Metabolic Disease Relapse Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • L. Sjöström
    • 1
  • T. William-Olsson
    • 1
  1. 1.Department of Medicine ISahlgren’s Hospital, University of GöteborgGöteborgSweden

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