Abstract
We have studied the effects of the inclusion of acarbose in a high carbohydrate diet fed to rats with type I diabetes (streptozotocin-treated) and to rats with genetically induced type II diabetes (SHR/N-cp rats). Although the SHR/N-cp rats had only a slightly elevated fasting blood sugar, the oral glucose tolerance curve in these rats was markedly higher than that in normal rats. Administration of acarbose for 5 weeks (10 mg/100 g diet) greatly improved glucose tolerance in the type II diabetic antimals. In streptozotocin-diabetic rats, in which fasting blood sugar was extremely high, feeding of acarbose had little or no effect on the hyperglycemia.
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© 1988 Springer-Verlag Berlin Heidelberg
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Hess, M.E., Haugaard, N., Torbati, A., Rastogi, A., Tulp, O.L. (1988). Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats. In: Creutzfeldt, W. (eds) Acarbose for the Treatment of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73583-7_15
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DOI: https://doi.org/10.1007/978-3-642-73583-7_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-19145-2
Online ISBN: 978-3-642-73583-7
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