Immunologische und virologische Befunde bei japanischen Patienten mit Adult T-cell leukemia

  • K. Nishio

Zusammenfassung

Als Adult T-cell leukemia (ATL) ist eine besonders in Japan endemisch gehäufte Sonderform der T-Cell-Leukämie in den letzten Jahren erkannt und immunologisch sowie virologisch schrittweise aufgeklärt worden. Die Erkrankung wird durch ein Retrovirus vom Typ HTLV-I hervorgerufen, das ebenso wie andere HTLV-Typen Inducer-T-Zellen angreift und zur malignen Transformation der Zellen führt. In der gemischten Lymphocytenkultur unterdrücken diese Zellen aber die durch Mitogen-Stimulation hervorgerufene B-Zell-Differenzierung, entfalten in dieser Hinsicht also eine Suppressor-Aktivität. Für die immunserologische Diagnose von ATL ist der Nachweis von anti-ATLA-Antikörpern im Blutserum wichtig. In den letzten Jahren konnte als Ursache ein Retrovirus vom Typ HTLV-I gesichert werden. Anhand der Strukturanalyse des in die Wirtszell-DNA integrierten Provirus-Genoms ergeben sich auch molekularbiologische Modellvorstellungen über den Entstehungsmechanismus der ATL. Die Gründe für das unterschiedliche onkogene Potential der verschiedenen HTLV-Typen sind jedoch noch ungeklärt.

Summary

Increasing research work has recently been performed on ATL cells in different fields. According to immunological studies ATL cells could be characterized as inducer/helper cells. However, using PWM stimulation of B cells a suppressor activity of ATL cells could be achieved. Concerning cytogenetic analysis, an increased rate of chromosomal aberrations in ATL cells was found. The occurrence of anti-ATLA antibodies in the serum of ATL patients is important for the definite diagnosis of ATL, especially in areas non-endemic for ATL Virus. There is meanwhile good evidence for identity of ATLV and type I of human T-lymphotrophic virus (HTLV-I), which proved to be the causative agent of ATL. As belonging to the group of oncogenic RNA retroviruses, HTLV-I is able to insert cDNA into the genom of the infected host cells. Having been integrated into a non-specific region of the cellular DNA genom, cDNA can not be regarded as part of the endogenous genom (oncogenic pro virus). In this paper some results of recent studies concerning immunological and DNA-moleeular properties of ATL cells and HTLV-I resp., are presented.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. Nishio
    • 1
  1. 1.Department of Dermatology, School of MedicineUniversity of Occupational and Environmental Health807 KitakyushuJapan

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