Clinical Trials of the LH-RH Analogue Leuprolide in Human Breast Cancer
Leuprolide (D-leu6-Des Gly10-Pro9-NH Et-LH-RH) is a potent analogue of the hypothalamic human gonadotropin-releasing hormone (LH-RH). The function of the native hormone LH-RH is to cause episodic release of gonadotropins by the pituitary gland. The chronic administration of highly potent LH-RH analogues (superagonists) such as leuprolide, causes pituitary desensitization leading, paradoxically, to inhibition of LH and FSH and consequently, to decreased output of gonadal sex steroids (1–4). Effective tumor regression has been reported in female rats bearing the dimethyl-benz-anthrancene induced mammary carcinoma treated chronically with leuprolide . Thus, these physiologic considerations and experimental data provided a scientific rationale for conducting clinical trials of leuprolide and other LH-RH agonists in human breast cancer.
KeywordsBreast Cancer Estrogen Receptor Luteinizing Hormone Premenopausal Patient Chronic Therapy
Unable to display preview. Download preview PDF.
- 8.Harvey HA, Lipton A, Max DT (1984) LH-RH analogs for human mammary carcinoma. In: Vickery BH, Nestor JJ, Jr., Hafez ESE (eds) LH-RH and its analogs — contraceptive and therapeutic applications. MTP Press, Lancaster-Boston, p 329Google Scholar
- 11.Labrie F, Dupont A, Belanger A, Giguere M, Lacoursiere Y, Emond J, Monfette G, Bergeron V (1985) Combination therapy with flutamide and castration (LH-RH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival. J Steroid Biochem 23 (5B): 833–841PubMedCrossRefGoogle Scholar