Clinical Trials of the LH-RH Analogue Leuprolide in Human Breast Cancer

  • H. A. Harvey
  • A. Lipton
  • D. T. Max


Leuprolide (D-leu6-Des Gly10-Pro9-NH Et-LH-RH) is a potent analogue of the hypothalamic human gonadotropin-releasing hormone (LH-RH). The function of the native hormone LH-RH is to cause episodic release of gonadotropins by the pituitary gland. The chronic administration of highly potent LH-RH analogues (superagonists) such as leuprolide, causes pituitary desensitization leading, paradoxically, to inhibition of LH and FSH and consequently, to decreased output of gonadal sex steroids (1–4). Effective tumor regression has been reported in female rats bearing the dimethyl-benz-anthrancene induced mammary carcinoma treated chronically with leuprolide [5]. Thus, these physiologic considerations and experimental data provided a scientific rationale for conducting clinical trials of leuprolide and other LH-RH agonists in human breast cancer.


Breast Cancer Estrogen Receptor Luteinizing Hormone Premenopausal Patient Chronic Therapy 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. A. Harvey
  • A. Lipton
  • D. T. Max

There are no affiliations available

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