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Complication Rates of Radiotherapy with Adjuvant Chemotherapy for Conservative Treatment

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Breast Diseases

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Abstract

Over the last 30 years, it has not been possible to bring about any decisive improvements in the prognosis of carcinoma of the breast with radical treatment methods, since by the time most women with breast cancer undergo primary treatment they are already suffering from systemic tumor disease that can no longer be controlled by locoregional therapy, Fisher et al. [12] and Veronesi et al. [35] have shown that the results of less radical, breast-conserving treatments are no worse than those of the conventional radical treatment as far as DFS and OAS are concerned; Fisher bases this conclusion on a follow-up period of 5 years, while Veronesi had followed his patients for 10 years. In both cases, this proved true even for patients in whom histological examination had revealed positive lymph nodes. Nonetheless, we feel that adjuvant chemotherapy is essential when positive lymph nodes are present, at least for premenopausal women [27]. This raises the question of the tolerance of a combination of radiotherapy and adjuvant chemotherapy, especially as experimental studies conducted by Phillips et al. [28], Redpath [31], and Collins and Steel [10] have indicated that when radiotherapy is combined with chemotherapeutic regimens including cyclophosphamide and adriamycin the toxicity is synergistic.

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Authors
  1. M. Bauer
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  2. D. von Fournier
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  3. F. Kubli
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  4. H. Schmid
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  5. R. Schulz-Wendtland
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Editor information

Editors and Affiliations

  1. Women’s Hospital, University of Heidelberg, Voßstr. 9, D-6900, Heidelberg, Germany

    F. Kubli  & M. Kaufmann  & 

  2. Department of Gynecological Radiology, University Women’s Hospital, Hugstetterstr. 5, D-7800, Freiburg/Brsg., Germany

    M. Bauer

  3. Women’s Hospital and Clinic of Radiology, University of Heidelberg, Voßstr. 9, D-6900, Heidelberg, Germany

    D. von Fournier  & H. Junkermann  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Bauer, M., von Fournier, D., Kubli, F., Schmid, H., Schulz-Wendtland, R. (1989). Complication Rates of Radiotherapy with Adjuvant Chemotherapy for Conservative Treatment. In: Kubli, F., Bauer, M., Kaufmann, M., von Fournier, D., Junkermann, H. (eds) Breast Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73523-3_42

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  • DOI: https://doi.org/10.1007/978-3-642-73523-3_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73525-7

  • Online ISBN: 978-3-642-73523-3

  • eBook Packages: Springer Book Archive

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