Zusammenfassung
Erkrankungen des Herz-Kreislaufsystems zeichnen in der westlichen Welt noch immer für etwa die Hälfte aller Todesfälle verantwortlich. Die kausale Beziehung zwischen Störungen im Lipidstoffwechsel und Entwicklung arteriosklerotischer Gefäßerkrankungen wird heute fast universell akzeptiert. Die Grundlagen für unser Verständnis darüber wurden in großangelegten epidemiologischen Studien erarbeitet.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Blankenborn DH, Nessim SA, Johnson RL et al (1987) Beneficial effects of combined colestipolniacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 257: 3233–3240
Brown MS, Goldstein JL (1986) A receptor mediated pathway for cholesterol homeostasis. Science 232: 34–47
Carlson LA, Böttiger LE (1985) Risk factors for ischaemic heart disease in men and women: results of the 19-year follow-up of the Stockholm prospective study. Acta Med Scand 218: 207–211
Castelli WP, Garrison RJ, Wilson PWF et al (1986) Incidence of coronary heart disease and lipoprotein cholesterol levels: the Framingham study. JAMA 256: 2835–2838
Chen CH, Albers JJ (1985) Activation of lecithin: cholesterol acyltransferase by apolipoproteins E-2, E-3 and A-IV isolated from human plasma. Biochim Biophys Acta 836: 279–285
Europäischer Konsens zur Primärprävention der KHK (1986). MMW Extrablatt 48: 1–4
Fielding CJ, Shore VG, Fielding PE (1972) A protein cofactor of lecithin: cholesterol acyltransferase. Biochem Biophys Res Commun 46: 1493–1498
Frick MH, Elo O, Haapa K et al (1987) Helsinki-heart study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. N Engl J Med 317: 1237–1245
Glueck CJ, Fallat RW, Millet F et al (1975) Familial hyperalpha-lipoproteinemia: studies in eighteen kindreds. Metabolism 24: 1243–1265
Goldbourt V, Holtzman E, Neufeld HN (1985) Total and high density lipoprotein cholesterol in the serum and risk of mortality: evidence of a threshold effect. Br Med J 290: 1239–1243
Gordon T, Castelli WP, Hjortland MC et al (1977) High density lipoprotein as a protective factor against coronary heart disease. Am J Med 62: 707–714
Hui D, Brecht WJ, Hall EA et al (1986) Isolation and characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem 261: 4256–4267
Innerarity TL, Pitas RE, Mahley RW (1979) Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem 254: 4186–4190
Kannel WB, Castelli WP, Gordon T et al (1971) Serum cholesterol, lipoproteins, and risk of coronary heart disease: the Framingham study. Ann Intern Med 74: 1–12
Kannel WB, Castelli WP, Gordon T (1979) Cholesterol in the prediction of atherosclerotic disease: new perspectives based on the Framingham study. Ann Intern Med 90: 85–91
Kovanen PT, Bilheimer DW, Goldstein JL et al (1981) Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc Natl Acad Sci USA 78: 1194–1198
Lipid Research Clinics Program (1984 a) The lipid research clinics coronary primary prevention trial results. I. Reduction in incidence of coronary heart disease. JAMA 251: 351–364
Lipid Research Clinics Program (1984 b) The lipid research clinics coronary primary prevention trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 365–374
Mahley, RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo B, E and apo E receptors. J Clin Invest 68: 1197–1206
Miller GJ, Miller NE (1975) Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet 1: 16–19
Miller NE, Forde OH, Thelle DS, Mjos OD (1977) The Tromso heart-study: high-density lipoprotein and coronary heart-disease: a prospective casecontrol study. Lancet 1: 965–967
Multiple Risk Faktor Intervention Trial Group (1982) Multiple risk factor intervention trial: risk factor changes and morbidity results. JAMA 248: 1465–1467
Nielsson-Ehle P, Garfinkel AS, Schotz MC (1980) Lipolytic enzymes and plasma lipoprotein metabolism. Am Rev Biochem 49: 667–693
Oliver MF (1982) Risks of correcting the risks of coronary disease and stroke with drugs. N Engl J Med 306: 297–298
Phillips MC, Johnson WJ, Rothblat GH (1987) Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochim Biophys Acta 906: 223–276
Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project research group (1978). J Chronic Dis 31: 201–306
Rhoads GG, Gulbrandsen CL, Kagan A (1976) Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. N Engl J Med 294: 293–298
Ross R (1986) The pathogenesis of atherosclerosis - an update. N Engl J Med 314: 488–500
Solberg LA, Strong JP (1983) Risk factors and athersclerotic lesions: a review of autopsy studies. Arteriosclerosis 3: 187–198
Soutar AK, Garner CW, Baker HN et al (1975) Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin: cholesterol acyltransferase. Biochemistry 14: 3057–3064
Spady DK, Bilheimer DW, Dietschy JM (1983) Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster. Proc Natl Acad Sci USA 80: 3499–3503
Stamler J, Wentworth D, Neaton J (1986) Is the relationship between serum cholesterol and risk of death from coronary heart disease continuous or graded? JAMA 256: 2823–2828
Steinberg D, NIH Consensus Development Panel (1985) Lowering blood cholesterol to prevent heart disease. JAMA 253: 2080–2086
Steinmetz A, Utermann G (1985) Activation of lecithin: cholesterol acyltransferase by human apolipoprotein A-IV. J Biol Chem 260: 2258–2264
Steinmetz A, Kaffarnik H, Utermann G (1985) Activation of phosphatidylcholine-sterol acyl-transferase by human apolipoprotein E isoforms. Eur J Biochem 152: 747–751
Strategies for the prevention of coronary heart disease (1987) A policy statement for the European Atherosclerosis Society. Eur Heart J 8: 77–88
Zorich N, Jonas A, Pownall HJ (1985) Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids. J Biol Chem 260: 8831–8837
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Steinmetz, A. (1988). Epidemiologie und neue Richtwerte zur Behandlung der Hyperlipoproteinämien. In: Kaffarnik, H., Schneider, J., Steinmetz, A. (eds) Aktuelle Gesichtspunkte der Hyperlipoproteinämien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73478-6_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-73478-6_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-19023-3
Online ISBN: 978-3-642-73478-6
eBook Packages: Springer Book Archive