Abstract
The ultimate goal of occupational health practice and research with respect to the use of chemical substances at work is the prevention of adverse effects (Samuels 1986). Contrary to well-controlled experimental dose-effect studies, one is confronted in practice with a multitude of effect-modifying variables, influencing not only the dose but also the dose-effect relation ifself. Several interrelated phases can be distinguished in the process from source to final effects. These phases can be schematically modelled (Fig. 1). Referring to Zielhuis and Henderson (1986), we use “internal exposure” to refer to biological monitoring procedures and “biological effect” to refer to biological effect monitoring.
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© 1988 Springer-Verlag Berlin Heidelberg
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van Dijk, F.J.H., Meijman, T.F., Ulenbelt, P. (1988). Towards a Dynamic Model of Exposure, Susceptibility and Effect. In: Notten, W.R.F., Hunter, W.J., Herber, R.F.M., Monster, A.C., Zielhuis, R.L. (eds) Health Surveillance of Individual Workers Exposed to Chemical Agents. International Archives of Occupational and Environmental Health Supplement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73476-2_19
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DOI: https://doi.org/10.1007/978-3-642-73476-2_19
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