Abstract
The influence of physical activity on the disposition of chemical agents, mainly solvents, in blood and tissues of man has been studied by Zenz and Berg (1970), Åstrand et al. (1972, 1973) and Monster et al. (1979a, b) and was discussed in regard to physiological and practical aspects by Zielhuis (1971) and Åstrand (1975). Using physiological principles, the uptake of gaseous solvents, via the lungs, with a given concentration in ambient air (Ci) depends on (a) the pulmonary ventilation (intake = Ci × respiratory volume per unit time), (b) the diffusion of the solvent through the alveolar capillary membrane (uptake = intake × fraction resorption), (c) the solubility of the solvent in blood, (d) the circulation of blood through the lungs and other organs, (e) the diffusion of the solvent through tissue membrane, and (f) the solubility of the solvent in fatty tissues (Åstrand 1975).
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© 1988 Springer-Verlag Berlin Heidelberg
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Rutenfranz, J., Bolt, H.M. (1988). The Impact of Physical and Mental Activity on Toxicokinetics and Toxicodynamics of Workplace Chemicals. In: Notten, W.R.F., Hunter, W.J., Herber, R.F.M., Monster, A.C., Zielhuis, R.L. (eds) Health Surveillance of Individual Workers Exposed to Chemical Agents. International Archives of Occupational and Environmental Health Supplement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73476-2_15
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DOI: https://doi.org/10.1007/978-3-642-73476-2_15
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