Skip to main content
SpringerLink
Log in

Serum Mediators and the Generation of Immune Suppression

  • Conference paper
Immune Consequences of Trauma, Shock, and Sepsis

Abstract

Trauma is one of the most serious health care problems in the United States. It is the leading cause of mortality in the 1–40 year age group with more than 50 million injuries per year. In 1982 alone there were over 165 000 trauma deaths resulting in an economic impact of more than $88 billion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Walker RI (1984) The pathophysiology of combined injury and trauma. In: Walker RI, Gruber DF, MacVittie TJ, Conklin JJ (eds) The pathophysiology of combined injury and trauma. Bethesda, Armed Forces Radiobiology Research Institute, pp 3–8

    Google Scholar 

  2. Warden GD, Mason AD, Pruit BA (1974) Evaluation of leukocyte Chemotaxis in vitro in thermally injured patients. J Clin Invest 54: 1001–1004

    Article  PubMed  CAS  Google Scholar 

  3. Constantian MB, Menzoian JO, Nimberg RB et al. (1977) Association of a circulating immunosuppressive polypeptide with operative and accidental trauma. Ann Surg 185: 73–79

    Article  PubMed  CAS  Google Scholar 

  4. Hakim AA (1977) An immunosuppressive factor from serum of thermally traumatized patients. J Trauma 17: 908–919

    Article  PubMed  CAS  Google Scholar 

  5. Christou NV, Meakins JL (1983) Partial analysis and purification of polymorphonuclear neutrophil chemotactic inhibitors in serum from anergic patients. Arch Surg 118: 156–160

    Article  PubMed  CAS  Google Scholar 

  6. Ozkan AN, Ninnemann JL (1985) Circulating mediators in thermal injuries: isolation and characterization of a burn-injury induced immunosuppressive serum component. J Burn Care Rehabil 6: 147–151

    Article  PubMed  CAS  Google Scholar 

  7. Ozkan AN, Ninnemann JL (1985) Suppression of in vitro lymphocyte and neutrophil responses by a low molecular weight suppressor active peptide from burn patient sera. J Clin Immunol 5: 221–228

    Article  Google Scholar 

  8. Ozkan AN, Ninnemann JL (1986) Progress in the characterization of an immunosuppressive glycopeptide from patients with major thermal injuries. J Burn Care Rehabil 7: 388–397

    Article  PubMed  CAS  Google Scholar 

  9. Ozkan AN, Ninnemann JL (1987) Reversal of suppressor active peptide induced immunosuppression and SAP detection by a monoclonal antibody. J Trauma 27: 123–126

    Article  PubMed  CAS  Google Scholar 

  10. Krzystyniak K, Stacharska J, Ryzewski K et al. (1978) Suppressive effect of low molecular weight fibrinogen degradation products on human and rat lymphocytes. Thromb Res 12: 523–530

    Article  PubMed  CAS  Google Scholar 

  11. Edgington TS, Curtiss LK, Plow EF (1985) A linkage between the hemostatic and immune systems embodied in the fibrinolytic release of lymphocyte suppressive peptide. J Immunol 134: 471–477

    PubMed  CAS  Google Scholar 

  12. Plow EF, Edgington TS (1986) Lymphocyte suppressive peptides from fibrinogen are derived predominantly from the A alpha chain. J Immunol 137: 1910–1915

    PubMed  CAS  Google Scholar 

  13. Ehrlich MI, Krushell JS, Blumenstock FA et al. (1981) Depression of phagocytosis by plasmin degradation products of plasma fibronectin. J Lab Clin Med 98: 263–271

    PubMed  CAS  Google Scholar 

  14. Easter DW, Hoyt DB, Ozkan AN (1988) Immunosuppression by a peptide from the gelatin binding domain of human fibronectin. J Surg Res (in press)

    Google Scholar 

  15. Hoyt DB, Ozkan AN, Easter DW (1988) Isolation of an immunosuppressive trauma peptide and its relationship to fibronectin. J Trauma 28: 1–7

    Article  Google Scholar 

  16. Dayer JM, Trentham DE, Krane SM (1982) Collagens act as ligands to stimulate human monocytes to produce mononuclear cell factor and prostaglandins. Coll Relat Res 2: 523–540

    PubMed  CAS  Google Scholar 

  17. Ozkan AN, Ninnemann JL (1985) Burn-associated suppressor active peptide: relationship to tissue collagen. Proc Am Burn Assoc 15: 50

    Google Scholar 

  18. Clowes GH, George BC, Villee CA et al. (1983) Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. N Engl J Med 308: 545–552

    Article  PubMed  Google Scholar 

  19. Ozkan AN, Hoyt DB, Mitchell MD et al. (1988) Trauma peptide mediated prostaglandin E2 biosynthesis: a potential mechanism for trauma-induced immunosuppression. Immunol Lett 17: 79–83

    Article  PubMed  CAS  Google Scholar 

  20. Rodrick ML, Wood JJ, O’Mahony JB et al. (1986) Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man. Production of interleukin-1 and -2. J Clin Immunol 6: 310–318

    Article  PubMed  CAS  Google Scholar 

  21. Wood JJ, O’Mahony JB, Rodrick ML et al. (1986) Abnormalities of antibody production after thermal injury: an association with reduced interleukin 2 production. Arch Surg 121: 108–115

    Article  PubMed  CAS  Google Scholar 

  22. Tompkins SD, Gregory S, Hoyt DB et al. (1988) Inhibition of IL-2 biosynthesis by a trauma-induced glycopeptide. FASEB J 2: 8978

    Google Scholar 

  23. Pinney E, Hoyt DB, Ozkan AN (1988) The effect of a trauma-induced immunosuppressive peptide on phorbol ester activated T lymphocyte. FASEB J 2: 8974

    Google Scholar 

  24. Colombani PM, Robb A, Hess AD (1985) Cyclosporin a binding to calmodulin: a possible site of action on T lymphocytes. Science 19: 337–339

    Article  Google Scholar 

  25. Le Grue SJ, Munn CG (1986) Comparison of the immunosuppressive effects of cyclosporin, lipid soluble anesthetics and calmodulin antagonists. Transplantation 42: 679–685

    Article  Google Scholar 

  26. Ozkan AN, Hoyt DB, Ninnemann JL (1987) Generation and activity of suppressor peptides following traumatic injury. J Burn Care Rehabil 8: 527–530

    PubMed  CAS  Google Scholar 

  27. Ozkan AN, Pinney E, Hoyt DB et al. (1988) Protease and suppressor active peptide activity following burn injury. J Trauma (in press)

    Google Scholar 

  28. Mary D, Aussel C, Ferrua B et al. (1987) Regulation of interleukin 2 synthesis by cAMP in human T cells. J Immunol 139: 1179–1184

    PubMed  CAS  Google Scholar 

  29. Imboden JB (1988) The regulation of intracellular signals during lymphocyte activation. Immunol Today 9: 17–18

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. N. Ozkan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. of Surgery, LM University Munich Klinikum Großhadern, Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist

  2. University of California, San Diego, California, 92103, USA

    John L. Ninnemann Ph. D. (Associate Adjunct Professor of Surgery) (Associate Adjunct Professor of Surgery)

  3. University of Alberta Edmonton, Alberta, T6G 2H7, Canada

    Douglas R. Green Ph. D. (Associate Professor of Immunology) (Associate Professor of Immunology)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Ozkan, A.N. (1989). Serum Mediators and the Generation of Immune Suppression. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73468-7_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation