Role of T-Cell Lymphocyte Populations and Their Products as Mediators of Immune Depression in Thermal Burns
Helper T cells and suppressor T cells represent critical immunological subsets involved in resistance to bacteria in thermally injured patients [1–4]. Activated T cells secrete soluble mediators of immune reactions called lymphokines [5, 6]. Two lymphokines, interleukin 1 and interleukin 2, have been demonstrated to be of particular importance to host defense mechanisms against microbial invasion [7–10].
KeywordsMigration Depression Allo
Unable to display preview. Download preview PDF.
- 1.Loor F, Roelants GE (1977) B and T cells in immune recognition. Wiley, LondonGoogle Scholar
- 2.Miller CL (1981) Secondary immunodeficiency in burns and after surgical trauma. Clin Immunol Allergy 1 (3): 641Google Scholar
- 3.Waldman TA (1978) Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity. Ann Intern Med 88: 226Google Scholar
- 4.Cantor H, Boyse E (1977) Regulation of immune response by T cell subclasses. In: Stutman O (ed) Contemporary topics in immunobiology, vol 7. Plenum, New YorkGoogle Scholar
- 6.Gerson RK, Naidorf KF (1980) Information transfer between T cell sets: the macrophage is the message. In: Unane ER, Rosenthal AS (eds) Macrophage regulation of immunity. Academic, New York, p 431Google Scholar
- 7.Unane ER, Rosenthal AS (1980) Macrophage regulation of immunity. Academic, New YorkGoogle Scholar
- 9.Miller SE, Miller CL, Trunkey DD (1982) The immune consequences of trauma. Surg Clin North Am 62 (no 1)Google Scholar
- 16.Ninneman JL, Fisher JC, Wachtel TL (1979) Thermal injury associated immunosuppression: occurrence and in vitro blocking effect of post recovery serum. J Immunol 122: 1736Google Scholar
- 19.Calvano Se, Chiao J, Antonacci AC, Shires GT (1984) Changes in rat lymphoid organ lymphocyte subpopulations following thermal injury. Surg ForumGoogle Scholar
- 20.Munster AM (1977) Post-traumatic immunosuppression is due to activation of suppressor T cells. Lancet I: 1329Google Scholar
- 22.Miller CL (1981) Alteration in macrophage function following thermal injury. In: Ninneman JL (ed) The immune consequences of thermal injury. Williams and Wilkins, Baltimore, p 49Google Scholar