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Alterations of Monocyte Function Following Major Injury

  • Conference paper
Immune Consequences of Trauma, Shock, and Sepsis

Abstract

Alteration in monocyte/macrophage (MØ) functions post-trauma increasingly appears to be related to the development of post-trauma immunoincompetence and metabolic derangement [1–11]. These inimical post-trauma alterations in monocytes can be categorized into three types: (1) depression in antigen-presenting function due to alterations in antigen processing or presentation, (2) alterations in monokine secretion, and (3) stimulation of inhibitory MØ factor production. Our hypothesis is that a post-trauma shift in the ratio of MØ subsets may be causal in all three of these types of monocyte defects.

This study was supported by grants GM36214 and DAMD 17-86-C-6091 from the U.S. Public Health Service.

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Authors
  1. C. L. Miller-Graziano
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  2. G. Szabo
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  3. T. Takayama
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  4. Jia-yan Wu
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, LM University Munich Klinikum Großhadern, Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist

  2. University of California, San Diego, California, 92103, USA

    John L. Ninnemann Ph. D. (Associate Adjunct Professor of Surgery) (Associate Adjunct Professor of Surgery)

  3. University of Alberta Edmonton, Alberta, T6G 2H7, Canada

    Douglas R. Green Ph. D. (Associate Professor of Immunology) (Associate Professor of Immunology)

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© 1989 Springer-Verlag, Berlin Heidelberg

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Miller-Graziano, C.L., Szabo, G., Takayama, T., Wu, Jy. (1989). Alterations of Monocyte Function Following Major Injury. In: Faist, E., Ninnemann, J.L., Green, D.R. (eds) Immune Consequences of Trauma, Shock, and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73468-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-73468-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73470-0

  • Online ISBN: 978-3-642-73468-7

  • eBook Packages: Springer Book Archive

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