Abstract
It has been suggested that the vasodilator neuropeptides may be involved in both the control of blood pressure and the antihypertensive effect of the angiotensin-converting enzyme inhibitor captopril (Ajayi et al. 1985). The angiotensin-converting enzyme has many similarities to a membrane-bound enzyme which inactivates metenkephalin (Beruck and Marks 1979), and captopril has been said to increase enkephalin levels in patients with migraine (Baldi et al. 1983). In experimental models angiotensin-converting enzyme inhibition has also been shown to block the increase in plasma beta-endorphins produced by angiotensin I (Beuers et al. 1982). In normal volunteers angiotensin-converting enzyme inhibition with enalapril did not alter metenkephalins (VandenBurg et al. 1985), and in hypertensive patients beta-endorphins were not affected (VandenBurg et al. 1984).
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© 1988 Springer-Verlag Berlin Heidelberg
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Brandman, S., Wiseman, W.T., Stephens, J.D., Long, C., Glover, D.R., Vandenburg, M.J. (1988). Effect of Lisinopril on Circulating Neuropeptides in Essential Hypertensive Patients. In: Stumpe, K.O., Kraft, K., Faden, A.I. (eds) Opioid Peptides and Blood Pressure Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73429-8_31
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DOI: https://doi.org/10.1007/978-3-642-73429-8_31
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