Abstract
It is well established that macrophages are very important in host defence, including the elimination of tumour cells. Macrophages contribute to host defence by phagocytosis, cytotoxic activity and immune regulation (Allison et al. 1978; Nathan et al. 1980). Mast cells are best characterized for their role in immediate hypersensitivity reactions. However, they also have other functions in host defence. They have been shown to phagocytose, though less efficiently than macrophages (Otani et al. 1982), and kill tumour cells (Tharp et al. 1986). With certain types of tumours, the mast cell number is greatly increased (Burtin 1986). The functional significance of mast cells in tumour control has been confirmed by the observation that the tumour incidence is increased in mast cell deficient mice (Burtin 1986). Mast cells also seem to be important in the initiation of inflammation, and certain tumours are associated with intense inflammatory reactions. We have observed that the influx of polymorphonuclear leukocytes in inflammation is markedly reduced in mast cell deficient mice (Qureshi and Jakschik 1987). Mast cells as well as macrophages are positioned in the tissue where noxious material may enter. They have the capacity to initiate processes which could eliminate unwanted material or cells.
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References
Allison AC, Ferluga J, Prydz H, Schorlemmer HU (1978) The role of macrophage activation in chronic inflammation. Agents Action 8:27–35
Baggiolini M, Horisberger U, Ulrich M (1982) Phagocytosis of mast cell granules by mononuclear phagocytes, neutrophils and eosinophils during anaphylaxis. Int Arch Allergy Appl Immunol 67:219–226
Burtin C (1986) Mast cells and tumor growth. Ann Inst Pasteur Immunol. 137D:289–294
Farrar WL, Humes JL (1985) The role of arachidonic acid metabolism in the activities of interleukin 1 and 2. J Immunol 135:1153–1159
Ford-Hutchinson AW, Bray M, Doig MV, Shipley ME, Smith MJ (1980) Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286:264–265
Goodwin JS (1981) Prostaglandins and host defence in cancer. Med Clin North Am 65:829–843
Humes JL, Burger S, Galavage M, Kuehl FA, Wrightman PD, Davies P, Bonney RJ (1980) The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms. J Immunol 124:2110–2116
Humes JL, Sadowski S, Galavage M, Goldberg M, Subers E, Bonney RJ, Kuehl FA Jr (1982) Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages. J Biol Chem 257:1591–1594
Jakschik BA, Rengers TA, Pinski JR (1987a) Nature of the mast cell-macrophage interaction in immediate hypersensitivity. Adv Prostaglandin Thromboxane Leukotriene Res 17:180–185
Jakschik BA, Wei YF, Rengers TA (1987b) Modulation of eicosanoid production due to mast cell-macrophage interaction. Adv Prostaglandin Thromboxane Leukotriene Res 16:141–152
Kruger PG, Lagunoff D, Wan H (1980) Isolation of intact mast cell granules with intact membranes. Exp Cell Res 129:83–93
Nathan CF, Murray HW, Cohn ZA (1980) The macrophage as an effector cell. N Engl J Med 303:622–626
Otani I, Conrad HD, Carlo JR, Segal DM, Ruddy S (1982) Phagocytosis by rat peritoneal mast cells: independence of IgG Fc-mediated and C3-mediated signals. J Immunol 129:2109–2112
Qureshi R, Jakschik BA (1987) The role of mast cells in inflammation. Fed Proc 46:985
Rola-Pleszczynski M (1985) Immunoregulation by leukotrienes and other lipoxygenase metabolites. Immunol Today. 6:302–307
Rola-Pleszczynski M, Gagnon L (1986) Natural killer function modulated by leukotriene B4: Mechanism of action. Transplant Proc [Suppl 4] 18:44–48
Rouzer AZ, Scott WA, Hamill AL, Cohn ZA (1980) Dynamics of leukotriene C4 production by macrophages. J Exp Med 152:1236–1247
Scott WA, Zrike JM, Kempe J, Cohn ZA (1980) Regulation of arachidonic acid metabolites in macrophages. J Exp Med 152:324–335
Tharp M, Thiele D, Charley M, Sullivan T (1986) Studies on the mechanism of mast cell killing of tumor cells. Fed Proc 45:850
Wei Y, Heghinian K, Bell RL (1986) Contribution of macrophages to immediate hypersensitivity reaction. J Immunol 137:1993–2000
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© 1988 Springer-Verlag Berlin Heidelberg
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Jakschik, B.A., Wei, Y., Owens, L.F. (1988). Interaction of Macrophages and Mast Cells in the Production of Prostaglandins and Leukotrienes. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_8
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DOI: https://doi.org/10.1007/978-3-642-73424-3_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18932-9
Online ISBN: 978-3-642-73424-3
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