Abstract
It is a well-established fact that eicosanoids participate in the initiation and promotion of carcinogenesis and that they have a close relationship to tumour promoters and growth factors. High concentrations of Prostaglandins have been found in the blood or urine of tumour-bearing animals (Levine 1981). We have also shown in malignant tumours of the breast (Nigam et al. 1985) and the gastrointestinal tract (Nigam et al. 1987) that increased levels of eicosanoids remained unchanged even after surgical removal of the tumour. The mechanism for this elevation is still unknown. Clinical data, however, present evidence that about 50% of the patients with malignant breast cancer who had elevated levels of eicosanoids after surgery were later rehospitalized on account of recidivism (unpublished results).
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Nigam, S.K., Averdunk, R. (1988). Alteration of Arachidonic Acid Metabolism in Rats after Inoculation of Tumour Cells and Their Subcellular Fractions: Role of Mononuclear Phagocytes as a Major Source of Enhanced Prostanoid Synthesis. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_5
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DOI: https://doi.org/10.1007/978-3-642-73424-3_5
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