Abstract
Macrophage functions are, at least in part, controlled by metabolites of the cyclo-oxygenase and 5-lipoxygenase pathways of arachidonic acid. For example macrophage lysosomal enzyme secretion is stimulated by the 5-lipoxygenase product leukotriene (LT)C4 and inhibited by the cyclo-oxagenase metabolic Prostaglandin (PG)E2. Further, the stimulatory action of LTC4 is enhanced by inhibitors of cyclo-oxygenase (Schenkelaars anf Bonta 1986). Also the discharge of the Polypeptide interleukin-1 (IL-1) is regulated by eicosanoids. Inhibition of the biosynthesis of PGE2 and exposure to LTB4 or LTD4 can augment the IL-1 production by monocytes (Rola-Pleszczynski and Lemaire 1985). Thus it appears that macrophages are stimulated by 5-lipoxygenase leukotrienes and inhibited by PGE2. In order to test the application of this concept to other than secretory functions, we investigated the influence of inhibitors of eicosanoid production on the cytostatic activity of macrophages towards a tumour cell line.
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© 1988 Springer-Verlag Berlin Heidelberg
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Bonta, I.L., Elliott, G.R. (1988). Eicosanoid Regulation of Macrophage In Vitro Cytostatic Function Towards Tumour Cells. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_3
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DOI: https://doi.org/10.1007/978-3-642-73424-3_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-18932-9
Online ISBN: 978-3-642-73424-3
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