Abstract
Reactive oxygen species have been shown to occur as a normal part of aerobic life, and they can lead to toxicity in cells and organs (for reviews, see Chance et al. 1979; Sies 1985, 1986). This is of importance in pathophysiological conditions such as carcinogenesis, inflammation, radiation damage, and also in drug and xenobiotic toxicity. Reactive oxygen species are also generated in the process of redox cycling, as used in chemotherapy, and there are indications that they are also formed during alcohol metabolism. A balance between pro-oxidant and antioxidant capacities is normally maintained in cells, and a disbalance in favour of pro-oxidants has been called oxidative stress. The most recent reviews on the many aspects in this field from our group are available (Sies 1986, 1987a–c; Sies et al. 1987a, b).
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References
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© 1988 Springer-Verlag Berlin Heidelberg
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Sies, H. (1988). Biochemistry of Oxidative Stress: Recent Experimental Work. In: Nigam, S.K., McBrien, D.C.H., Slater, T.F. (eds) Eicosanoids, Lipid Peroxidation and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73424-3_19
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DOI: https://doi.org/10.1007/978-3-642-73424-3_19
Publisher Name: Springer, Berlin, Heidelberg
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