Plasma Amino Acids and Suicidal Behavior: An Investigation of Different Groups of Patients Who Attempted to Commit Suicide

  • J. Demling
  • K. Langer
  • W. Stein
  • R. Höll
  • R. Kalb
Conference paper

Abstract

Biochemical findings in depressed (Coppen 1967) and suicidal patients as well as the results of studies on neuronal activity of psychotropic drugs (Fuxe et al. 1977) permit the conclusion that certain subgroups of depressions are due to some functional deficiency of central serotonergic neuronal systems.

Keywords

Depression Tyrosine Cortisol Schizophrenia Serotonin 

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References

  1. Åsberg M, Träskman L, Thorén P (1976) 5-HIAA in the cerebrospinal fluid — a biochemical suicide predictor? Arch Gen Psychiatry 33:1193–1197PubMedCrossRefGoogle Scholar
  2. Badawy AA, Evans M (1982) Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by acute administration of small doses of antidepressants. Br J Pharmacol 77 (1):59–67PubMedGoogle Scholar
  3. Branchey L, Branchey M, Shaw S, Lieber CS (1984) Depression, suicide, and aggression in alcoholics and their relationship to plasma amino acids. Psychiatry Res 12 (3):219–226PubMedCrossRefGoogle Scholar
  4. Coppen A (1967) The biochemistry of affective disorders. Br J Psychiatry 113:1237–1264PubMedCrossRefGoogle Scholar
  5. DeMyer MK, Shea PA, Hendrie HC, Yoshimura NN (1981) Plasma tryptophan and five other amino acids in depressed and normal subjects. Arch Gen Psychiatry 38 (6):642–646PubMedCrossRefGoogle Scholar
  6. Fernstrom JD, Wurtman RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178:414–416PubMedCrossRefGoogle Scholar
  7. Fernstrom JD, Hirsch MJ, Faller DV (1976) Tryptophan concentrations in rat brain: failure to correlate with serum free tryptophan, or its ratio to the sum of other serum neutral amino acids. Biochem J 160:589–595PubMedGoogle Scholar
  8. Fuxe K, Ogren S, Agnati L, Gustafsson JA, Jonsson G (1977) On the mechanism of action of the antidepressant drugs amitryptiline and nortriptyline. Evidence for 5-hydroxy-tryptamine receptor blocking activity. Neurosci Lett 6:339–343PubMedCrossRefGoogle Scholar
  9. Hanssen HP, Agarwal DP, Gerdes S, Goedde HW (1986) Studies on tryptophan pyrrolase activity in post-mortem liver homogenates. Abstract (F8), International Study Group for Tryptophan Research, 5th international meeting, Cardiff, July 28–August 1Google Scholar
  10. McMenamy RH, Oncley JL (1958) The specific binding of L-tryptophan to serum albumin. J Biol Chem 233:1435–1447Google Scholar
  11. Mehler AH, McDaniel EG, Hundley JM (1958) Changes in the enzymatic composition of liver: (II) influence of hormones on picolinic carboxylase and tryptophan Peroxydase. J Biol Chem 232:331–335PubMedGoogle Scholar
  12. Moller SE (1985) Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatr Scand [Suppl 325] 72:3–31CrossRefGoogle Scholar
  13. Møller SE, Kirk L, Brandrup E, Hollnagel M, Kaldan B, Odum K (1983) Tryptophan availability in endogenous depression — relation to efficacy of L-tryptophan treatment. In: van Praag HM, Mendlewicz J (eds) Advances in biological psychiatry, vol 10: management of depression with monoamine precursors. Karger, Basel, p 30Google Scholar
  14. Moore S, Stein WH (1951) Chromatography of amino acids on sulfonated polystyrene resins. J Biol Chem 192:663–681PubMedGoogle Scholar
  15. Pardridge WM (1979) Tryptophan transport through the blood-brain barrier: in vivo measurement of free and albumin-bound amino acid. Life Sci 25:1519–1528PubMedCrossRefGoogle Scholar
  16. Wirz-Justice A, Richter R (1979) Seasonality in biochemical determinations: a source of variance and a clue to the temporal incidence of affective illness. Psychiatry Res 1:53–60PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Demling
  • K. Langer
  • W. Stein
  • R. Höll
  • R. Kalb

There are no affiliations available

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