Alloantigens on leukocytes and platelets: Biochemistry

  • Michael J. Crumpton
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 2)

Abstract

Alloantigens of leukocytes and platelets are coded by genes located in the class I and II regions of the HLA complex. The class I region has at least 17 genes of which the HLA-A,B and C loci code for a glycosylated transmembrane polypeptide of 43kDa (kilo Daltons) which is associated non-covalently with β2-microglobulin a non-glycosylated, non-polymorphic 12kDa polypeptide. The 43kDa polypeptide comprises three domains ( α1, α2, α3 ) on the cell surface.

Keywords

Polypeptide 

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Michael J. Crumpton
    • 1
  1. 1.Imperial Cancer Research FundLondonUK

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