Genetic Polymorphism of Urinary Pepsinogen (PGA) Detected by Immunoblotting
Pepsinogen is classified into two immunochemically distinct groups, PGA and PGC. PGA is detected in serum and urine as uropepsinogen, and while PGC is present in serum and seminal fluid. Genetic models of PGA have been proposed by several investigators (Samloff and Townes 1970; Taggart et al. 1979; Korsnes and Gedde-Dahl 1980; Frants et al. 1984), who have used all the proteolytic properties of acid-activated PGA for the detection of the isozymogens on agar or polyacrylamide gels. However, the complexities of these techniques have yielded a number of conflicting results, leading to various different genetic models.
KeywordsGenetic Model Human Urine Seminal Fluid Blotting Transfer Normal Human Urine
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