Advertisement

Agarose Isoelectric Focusing for Classification of Plasminogen - Variants

  • H.-J. Leifheit
  • J. Howe
  • A. G. Gathof
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 2)

Abstract

Plasminogen (PLG) is the inactive precursor of plasmin. It is a plasmaprotein of the ß-fraction, the quantity in serum varies from 6–25 mg/dl. PLG has a molecular weight of 91.000 (Summaria et al. 1976), the part of carbohydrate is 1.5 % (Hayes, Castellino 1979).

Keywords

Genetic Polymorphism Common Allele Heating Plate Inactive Precursor Electrode Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cortivo P, Caenazzo L, Crestani C, Scorretti C, Benciolini P, Ponaro E (1986) The polymorphism of plasminogen (PLG) by ultra-thin-layer isoelectric focusing, Distribution in the Veneto population (Italy). Z Rechtsmed 96 (4), p 275.PubMedCrossRefGoogle Scholar
  2. Dykes DD (1983) Distribution of plasminogen allotypes in eight populations of the Western Hemisphere. Electrophoresis 4, p 417.Google Scholar
  3. Eiberg H, Mohr J, Nielsen (1981) Genetics and linkage relations of plasminogen. Clin Genet 19, p 500.Google Scholar
  4. Hayes ML, Castellino FJ (1979) Carbohydrate of the Human Plasminogen Variants I, II, III. J. Biol. Chem. 254, p 8786.Google Scholar
  5. Hitzeroth HW, Skoda U, du Toit E, Mauff G (1986) The plasminogen polymorphism in South African Negro populations: genetics and anthropogenetics. Hum Genet 74, p 341.PubMedCrossRefGoogle Scholar
  6. Hobart MJ (1979) Genetic polymorphism of human plasminogen. Ann Hum Genet 42, p 419.PubMedCrossRefGoogle Scholar
  7. Hummel K, Jäger H, Krüger HJ (1983) Bestimmung der Phänotypenhäufigkeiten im Plasminogen (PLG)-System bei Einwohnern der Stadt Mexiko. Ärztl Lab 29, p 198.Google Scholar
  8. Kühnl P, Spielmann W (1982) Erfahrungen mit neueren Blutgruppensystemen für die Vaterschaftsbegutachtung: FXIIIA und FXIIIB, PLGN, AMY2, GAA, GDH, PGM1-Thermostabi1itätsvarianten. Ärztl Lab 28, p 367.Google Scholar
  9. Leifheit H-J, Gathof AG, Cleve H (1987) Plasminogen (PLG) - Typisierung mittels isoelektrischer Fokussierung auf Agarose-Gelen und Immunfixation. Ärztl Lab 33, p 10.Google Scholar
  10. Mauff G, Erfurdt U, Pulverer G (1981) The application of human plasminogen (PLG) polymorphism to paternity testing. Lecture 10th Int Cong Forensic Hemo, p 531.Google Scholar
  11. Nakamura S, Abe K (1982) Genetic polymorphism of human plasminogen variants and relationship between plasminogen phenotypes and their biological activities. Hum Genet 60, p 57.PubMedCrossRefGoogle Scholar
  12. Nishigaki T, Omoto K (1982) Genetic polymorphism of human plasminogen in Japanese: Correspondence of alleles thus far reported in Japanese and difference of activity among phenotypes. Jpn J Hum Genet 27, p 341.CrossRefGoogle Scholar
  13. Nishimukai H, Shinmyozu K, Tamaki Y (1986) Polymorphism of plasminogen in healthy individuals and patients with cerebral infarction. Hum Hered 36, p 137.PubMedCrossRefGoogle Scholar
  14. Raum D, Marcus D, Alper CA (1979) Genetic control of human plasminogen (PLG). Clin Res 27, p 458.Google Scholar
  15. Raum D, Marcus D, Alper CA (1980) Genetic polymorphism of human plasminogen. Am J Hum Genet 32, p 681.PubMedGoogle Scholar
  16. Skoda U, Bertrams J, Dykes D, Eiberg H, Hobart M, Hummel K, Kühnl P, Mauff C, Nakamura S, Nishimukai H, Raum D, Tokunaga K, Weidinger S (1986) Proposal for the Nomenclature of Human Plasminogen (PLG) Polymorphism. Vox Sang 51, p 244.PubMedCrossRefGoogle Scholar
  17. Summaria L, Spitz F, Arzadon L, Boreisha IG, Robbins KC (1976) Isolation and Characterization of the Affinity Chromatography Forms of Human Glu- and Lys-Plasminogens and Plasmins. J Biol Chem 251, p 3693.PubMedGoogle Scholar
  18. Weidinger S, Schwarzfischer F, Müller H, Cleve H (1985) Plasminogen (PLG): A Useful Genetic Marker for Paternity Examinations. Z Rechtsmed 94, p 165.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H.-J. Leifheit
    • 1
  • J. Howe
    • 1
  • A. G. Gathof
    • 1
  1. 1.Blood Transfusion Service of the Bavarian Red CrossMunichGermany

Personalised recommendations