Human Red Cell Acid Phosphatase (ACP1): Evidence for Differences in the Primary Structure of the two Isozymes Expressed by each Allele
One of the notable features of human red cell acid phosphatase (ACP1, E.C. 126.96.36.199) is the generation of 2 isozymes (f and s) by each allele. These isozymes differ with respect to electrophoretic mobility (fig. 1) as well as to catalytic, stability and immunochemical properties (Harris 1980, Dissing 1987). The mechanism responsible for this pair wise production of isozymes has long been a puzzle and is of interest not only to the biochemist and geneticist but also to the forensic scientist.
KeywordsAcid Phosphatase Reverse Phase HPLC Analysis Single Amino Acid Residue Immunochemical Property Dimensional Thin Layer
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- Dissing J, Sensabaugh GF (to be published) Human red cell acid phosphatase (ACPI): Evidence for differences in the primary structure of the two isozymes encoded by the ACP1*B allele. Biochem GenetGoogle Scholar
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