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Human Red Cell Acid Phosphatase (ACP1): Evidence for Differences in the Primary Structure of the two Isozymes Expressed by each Allele

  • J. Dissing
  • G. F. Sensabaugh
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 2)

Abstract

One of the notable features of human red cell acid phosphatase (ACP1, E.C. 3.1.3.2) is the generation of 2 isozymes (f and s) by each allele. These isozymes differ with respect to electrophoretic mobility (fig. 1) as well as to catalytic, stability and immunochemical properties (Harris 1980, Dissing 1987). The mechanism responsible for this pair wise production of isozymes has long been a puzzle and is of interest not only to the biochemist and geneticist but also to the forensic scientist.

Keywords

Acid Phosphatase Reverse Phase HPLC Analysis Single Amino Acid Residue Immunochemical Property Dimensional Thin Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Dissing J (to be published) Immunochemical characterization of human red cell acid phosphatase isozymes. Biochem GenetGoogle Scholar
  2. Dissing J, Sensabaugh GF (to be published) Human red cell acid phosphatase (ACPI): Evidence for differences in the primary structure of the two isozymes encoded by the ACP1*B allele. Biochem GenetGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Dissing
    • 1
  • G. F. Sensabaugh
    • 2
  1. 1.Institute of Forensic GeneticsUniversity of CopenhagenCopenhagenDenmark
  2. 2.Forensic Science Group, School of Public HealthUniversity of CaliforniaBerkeleyUSA

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