Polymorphisms of Immunoglobulins: Gm, Am and Km Typing
Allotypes of immunoglobulins form the most polymorphic genetic system of human serum proteins. Allotypes have been shown on the heavy chains of IgG1, IgG2, IgG3, IgA2 and IgE and on kappa light chains, which are coded by the γ1, γ2, γ3, α2, ε and κ genes respectively. They are called G1m, G2m, G3m, A2m, Em and Km allotypes (Table 1). Most allotypes have originated from the genes by mutation of only one or a few nucleotides resulting in the difference of one or two amino acids. Until now 24 allotypes have been described: four G1m, one G2m, thirteen G3m, two A2m, one Em and three Km allotypes (ref 1).
KeywordsCoated Cell Kappa Light Chain Human Serum Protein Reference Seron R2R2 Cell
Unable to display preview. Download preview PDF.
- 1.Schanfield M.D., Loghem E. van (1986) Human immunoglobulin allotypes. Handbook of Experimental Immunology, 4th edition Ed. D.M. Weir Blackwell Scientific Publication, Vol 3 Chapter 94.Google Scholar
- 3.Review of the notation for the allotypic and related markers of human immunoglobulins. WHO meeting on human immunoglobulin allotypic markers, held 16–19 July 1974, Rouen, France, report amended June 1976. J. Immunogenet. 3, 357–362 (1976).Google Scholar