Abstract
Although the clinical problem of chronic daily headache induced by chronic intake of ergotamine tartrate and/or analgesics is known to clinicians (Lippman 1955; Horton et al. 1963; Rowsell et al. 1973; Wainscott et al. 1974; Andersson 1975; Ala-Hurula et al. 1982; Kudrow 1982; Saper 1983; Dichgans et al. 1984), no information is as yet available about the dosages of different drugs necessary to provoke this response. The patients’ histories show a gradual increase in frequency and dose of drug intake, eventually ending in daily administration of high dosages. It is unknown whether the daily intake itself or the drug dosage plays the crucial role.
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References
Aellig WH (1982) Agonists and antagonists of 5-hydroxytryptamine on venomotor receptors. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 321–324
Adlig WH (1984) Investigation of the venoconstrictor effect of 8’hydroxydihydroergotamine, the main metabolite of dihydroergotamine, in man. Eur J Clin Pharmacol 26:239–242
Ala-Hurula V, Myllylä V, Hokkanen E (1982) Ergotamine abuse: results of ergotamine discontinuation, with special reference to the plasma concentrations. Cephalalgia 2:189–195
Andersson PG (1975) Ergotamine headache. Headache 15:118–121
Babayan EA, Lepakhin VK, Rudenko GM (1980) Opioid analgesics and narcotic antagonists. In: Dukes MNG (ed) Meyler’s side effects of drugs. Excerpta Medica, Amsterdam, pp 102–122
Beaver WT (1981) Aspirin and acetaminophen as constituents of analgesic combinations. Arch Intern Med 141:293–300
Bruce M, Scott N, Lader M, Marks V (1986) The psychopharmacological and electrophysiological effects of single doses of caffeine in healthy human subjects. Br J Clin Pharmacol 22:81–87
Dichgans J, Diener HC, Gerber WD, Verspohl EJ, Kukiolka H, Kluck M (1984) Analgetika-induzierter Dauerkopfschmerz. Dtsch Med Wochenschr 109:369–373
Gibson T, Zaphiropoulos G, Grove J, Widdop B, Berry D (1975) Kinetics of salicylate metabolism Br J Clin Pharmacol 2:233
Henry P, Dartigues JF, Benetier MP, Lucas J, Duplan B, Jogeix M, Orgogozo JM (1985) Ergotamine-and analgesic-induced headaches. In: Rose FC (ed) Migraine. Proc 5th Int Migraine Symp London 1984. Karger, Basel, pp 197–205
Horton BT, Peters GA (1963) Clinical manifestations of excessive use of ergotamine preparations and management of withdrawal effect: report of 52 cases. Headache 3:214–226
Isler H (1982) Migraine treatment as a cause of chronic migraine. In: Rose FC (ed) Advances in migraine research and therapy. Raven, New York, pp 159–164
Kudrow L (1982) Paradoxical effects of frequent analgesic use. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology, vol 33. Raven, New york, 335–341
Langemark M, Olesen J (1984) Drug abuse in migraine patients. Pain 19:81–86
Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A (1984) Caffeine as an analgesic adjuvant. JAMA 251:1711–1718
Linblad B, Abisch E, Bergqvist D (1983) The pharmacokinetics of subcutaneous dihydroergotamine with and without dextran 70 infusion. Eur J Clin Pharmacol 24:813–818
Lippman CW (1955) Characteristic headache resulting from prolonged use of ergot derivatives. J Nery Ment Dis 121:270–273
Mathew RJ, Wilson WH (1985) Caffeine consumption, withdrawal and cerebral blood flow, Headache 25:305–309
Mathew NT, Stubits E, Nigam MP (1982) Transformation of episodic migraine into daily chronic headache: analysis of factors. Headache 22:66–68
Maurer G, Frick W (1984) Elucidation of the structure and receptor binding studies of the major primary metabolite of dihydroergotamine in man. Eur J Clin Pharmacol 26:463–470
Meadows BJ (1984) Codeine combinations in clinical practise. Curr Ther Res 35:501–510
Müller-Schweinitzer E, Fanchamps A (1982) Effects on arterial receptors of ergot derivatives used in migraine. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 343–356
Pincomb GA, Lovallo WR, Passay RB, Whitsett TL, Silverstein SM, Wilson MF (1985) Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. Am J Cardiol 56:119–122
Rapoport A, Weeks R, Sheftell F et al. (1985) Analgesic rebound headache: theoretical and practical implications. In: Olesen J, Tfelt-Hansen P, Jensen K (eds) Headache 1985. Proceedings of the second international headache congress. Jensen, Copenhagen, pp 448–449
Rowsell AR, Neylan C, Wilkinson M (1973) Ergotamine induced headaches in migrainous patients. Headache 13:65–67
Saper JR (1983) Drug abuse among headache patients. In: Saper JR (ed) Headache disorders: current concepts and treatment strategies. Wright, Boston, pp 263–278
Saxena PR (1982) Agonists and antagonists of vascular receptors. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 309–314
Svihovec J (1980) Anti-inflammatory analgesics and drugs used in gout. In: Dukes MNG (ed) Meyler’s side effects of drugs. Excerpta Medica, Amsterdam, pp 141–164
Tfelt-Hansen P (1986) The effect of ergotamine on the arterial system in man Acta Pharmacol Toxicol 59: [Suppl 3] 7–29
Tfelt-Hansen P, Eickhoff JH, Olesen J (1982) Duration of the biological effect of ergotamine tartrate. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 315–319
Wainscott G, Volans G, Wilkinson M (1974) Ergotamine induced headaches. Br Med J ii:724
Wilkinson M (1983) Treatment of the acute migraine attack — current status. Cephalalgia 3:61–67
Woodbury DM, Fingl E (1975) Analgesic-antipyretics, anti-inflammatory agents, and drugs employed in the therapy of gout. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 325–358
Woodcock BG, Loh W, Habedank W-D, Rietbrock N (1982) Dihydrotoxine kinetics in healthy men after intravenous and oral administration. Clin Pharmacol Ther 32:622–627
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© 1988 Springer-Verlag Berlin Heidelberg
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Scholz, E., Diener, HC., Geiselhart, S. (1988). Drug-Induced Headache — Does a Critical Dosage Exist?. In: Diener, HC., Wilkinson, M. (eds) Drug-Induced Headache. Advances in Applied Neurological Sciences, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73327-7_6
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DOI: https://doi.org/10.1007/978-3-642-73327-7_6
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