Skip to main content

Drug-Induced Headache — Does a Critical Dosage Exist?

  • Conference paper
Drug-Induced Headache

Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 5))

Abstract

Although the clinical problem of chronic daily headache induced by chronic intake of ergotamine tartrate and/or analgesics is known to clinicians (Lippman 1955; Horton et al. 1963; Rowsell et al. 1973; Wainscott et al. 1974; Andersson 1975; Ala-Hurula et al. 1982; Kudrow 1982; Saper 1983; Dichgans et al. 1984), no information is as yet available about the dosages of different drugs necessary to provoke this response. The patients’ histories show a gradual increase in frequency and dose of drug intake, eventually ending in daily administration of high dosages. It is unknown whether the daily intake itself or the drug dosage plays the crucial role.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aellig WH (1982) Agonists and antagonists of 5-hydroxytryptamine on venomotor receptors. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 321–324

    Google Scholar 

  • Adlig WH (1984) Investigation of the venoconstrictor effect of 8’hydroxydihydroergotamine, the main metabolite of dihydroergotamine, in man. Eur J Clin Pharmacol 26:239–242

    Article  Google Scholar 

  • Ala-Hurula V, Myllylä V, Hokkanen E (1982) Ergotamine abuse: results of ergotamine discontinuation, with special reference to the plasma concentrations. Cephalalgia 2:189–195

    Article  PubMed  CAS  Google Scholar 

  • Andersson PG (1975) Ergotamine headache. Headache 15:118–121

    Article  PubMed  CAS  Google Scholar 

  • Babayan EA, Lepakhin VK, Rudenko GM (1980) Opioid analgesics and narcotic antagonists. In: Dukes MNG (ed) Meyler’s side effects of drugs. Excerpta Medica, Amsterdam, pp 102–122

    Google Scholar 

  • Beaver WT (1981) Aspirin and acetaminophen as constituents of analgesic combinations. Arch Intern Med 141:293–300

    Article  PubMed  CAS  Google Scholar 

  • Bruce M, Scott N, Lader M, Marks V (1986) The psychopharmacological and electrophysiological effects of single doses of caffeine in healthy human subjects. Br J Clin Pharmacol 22:81–87

    PubMed  CAS  Google Scholar 

  • Dichgans J, Diener HC, Gerber WD, Verspohl EJ, Kukiolka H, Kluck M (1984) Analgetika-induzierter Dauerkopfschmerz. Dtsch Med Wochenschr 109:369–373

    Article  PubMed  CAS  Google Scholar 

  • Gibson T, Zaphiropoulos G, Grove J, Widdop B, Berry D (1975) Kinetics of salicylate metabolism Br J Clin Pharmacol 2:233

    CAS  Google Scholar 

  • Henry P, Dartigues JF, Benetier MP, Lucas J, Duplan B, Jogeix M, Orgogozo JM (1985) Ergotamine-and analgesic-induced headaches. In: Rose FC (ed) Migraine. Proc 5th Int Migraine Symp London 1984. Karger, Basel, pp 197–205

    Google Scholar 

  • Horton BT, Peters GA (1963) Clinical manifestations of excessive use of ergotamine preparations and management of withdrawal effect: report of 52 cases. Headache 3:214–226

    Article  Google Scholar 

  • Isler H (1982) Migraine treatment as a cause of chronic migraine. In: Rose FC (ed) Advances in migraine research and therapy. Raven, New York, pp 159–164

    Google Scholar 

  • Kudrow L (1982) Paradoxical effects of frequent analgesic use. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology, vol 33. Raven, New york, 335–341

    Google Scholar 

  • Langemark M, Olesen J (1984) Drug abuse in migraine patients. Pain 19:81–86

    Article  PubMed  CAS  Google Scholar 

  • Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A (1984) Caffeine as an analgesic adjuvant. JAMA 251:1711–1718

    Article  PubMed  CAS  Google Scholar 

  • Linblad B, Abisch E, Bergqvist D (1983) The pharmacokinetics of subcutaneous dihydroergotamine with and without dextran 70 infusion. Eur J Clin Pharmacol 24:813–818

    Article  Google Scholar 

  • Lippman CW (1955) Characteristic headache resulting from prolonged use of ergot derivatives. J Nery Ment Dis 121:270–273

    Article  CAS  Google Scholar 

  • Mathew RJ, Wilson WH (1985) Caffeine consumption, withdrawal and cerebral blood flow, Headache 25:305–309

    Article  PubMed  CAS  Google Scholar 

  • Mathew NT, Stubits E, Nigam MP (1982) Transformation of episodic migraine into daily chronic headache: analysis of factors. Headache 22:66–68

    Article  PubMed  CAS  Google Scholar 

  • Maurer G, Frick W (1984) Elucidation of the structure and receptor binding studies of the major primary metabolite of dihydroergotamine in man. Eur J Clin Pharmacol 26:463–470

    Article  PubMed  CAS  Google Scholar 

  • Meadows BJ (1984) Codeine combinations in clinical practise. Curr Ther Res 35:501–510

    Google Scholar 

  • Müller-Schweinitzer E, Fanchamps A (1982) Effects on arterial receptors of ergot derivatives used in migraine. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 343–356

    Google Scholar 

  • Pincomb GA, Lovallo WR, Passay RB, Whitsett TL, Silverstein SM, Wilson MF (1985) Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. Am J Cardiol 56:119–122

    Article  PubMed  CAS  Google Scholar 

  • Rapoport A, Weeks R, Sheftell F et al. (1985) Analgesic rebound headache: theoretical and practical implications. In: Olesen J, Tfelt-Hansen P, Jensen K (eds) Headache 1985. Proceedings of the second international headache congress. Jensen, Copenhagen, pp 448–449

    Google Scholar 

  • Rowsell AR, Neylan C, Wilkinson M (1973) Ergotamine induced headaches in migrainous patients. Headache 13:65–67

    Article  PubMed  CAS  Google Scholar 

  • Saper JR (1983) Drug abuse among headache patients. In: Saper JR (ed) Headache disorders: current concepts and treatment strategies. Wright, Boston, pp 263–278

    Google Scholar 

  • Saxena PR (1982) Agonists and antagonists of vascular receptors. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 309–314

    Google Scholar 

  • Svihovec J (1980) Anti-inflammatory analgesics and drugs used in gout. In: Dukes MNG (ed) Meyler’s side effects of drugs. Excerpta Medica, Amsterdam, pp 141–164

    Google Scholar 

  • Tfelt-Hansen P (1986) The effect of ergotamine on the arterial system in man Acta Pharmacol Toxicol 59: [Suppl 3] 7–29

    Google Scholar 

  • Tfelt-Hansen P, Eickhoff JH, Olesen J (1982) Duration of the biological effect of ergotamine tartrate. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology. Raven, New York, pp 315–319

    Google Scholar 

  • Wainscott G, Volans G, Wilkinson M (1974) Ergotamine induced headaches. Br Med J ii:724

    Google Scholar 

  • Wilkinson M (1983) Treatment of the acute migraine attack — current status. Cephalalgia 3:61–67

    Article  PubMed  CAS  Google Scholar 

  • Woodbury DM, Fingl E (1975) Analgesic-antipyretics, anti-inflammatory agents, and drugs employed in the therapy of gout. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 325–358

    Google Scholar 

  • Woodcock BG, Loh W, Habedank W-D, Rietbrock N (1982) Dihydrotoxine kinetics in healthy men after intravenous and oral administration. Clin Pharmacol Ther 32:622–627

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Scholz, E., Diener, HC., Geiselhart, S. (1988). Drug-Induced Headache — Does a Critical Dosage Exist?. In: Diener, HC., Wilkinson, M. (eds) Drug-Induced Headache. Advances in Applied Neurological Sciences, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73327-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73327-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73329-1

  • Online ISBN: 978-3-642-73327-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics