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Multiple Factors Involved in B-Cell Tumorigenesis

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Oncogenes and Growth Control

Abstract

This chapter considers the hypothesis that activation of the c-myc locus by chromosomal translocation to a site adjacent to one of the immunoglobulin loci represents an essential, rate-limiting step in the development of Burkitt’s lymphoma, mouse plasmacytoma, and rat immunocytoma. It also describes a possible mechanism by which an activated c-myc affects susceptible cells, as well as additional factors which may contribute to the acquisition of a malignant phenotype.

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Authors
  1. George Klein
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Editor information

Editors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10 22 09, 6900, Heidelberg, Germany

    Patricia Kahn  & Thomas Graf  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Klein, G. (1986). Multiple Factors Involved in B-Cell Tumorigenesis. In: Kahn, P., Graf, T. (eds) Oncogenes and Growth Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73325-3_44

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  • DOI: https://doi.org/10.1007/978-3-642-73325-3_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18760-8

  • Online ISBN: 978-3-642-73325-3

  • eBook Packages: Springer Book Archive

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