Regulation of c-myc Expression in Normal and Transformed Mammalian Cells
The c-myc proto-oncogene present in mammalian species is expressed in a wide variety of cell types. It consists of three exons (see Fig. 1) of which the first, approximately 560 nucleotides in length, is noncoding although evolutionarily conserved. The c-myc gene product is translated from exons 2 and 3. The transcripts have a size of 2.4 and 2.2 kb that are synthesized under the direction of two promoters, P1 and P2, respectively. Normal c-myc RNAs (Dani et al. 1985) and their 62–64 kDa polypeptide products (Hann and Eisenman 1984) are highly unstable in vivo. The c-myc protein has been localized within the nucleus and has been proposed to contribute to a cell’s competence to enter and progress through the cell cycle (see Moelling, this Vol., and Bravo and Müller, this Vol., and references therein).
KeywordsBurkitt Lymphoma Plasma Cell Tumor Burkitt Lymphoma Cell Proviral Insertion Heavy Chain Constant Region
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