Regulation of c-myc Expression in Normal and Transformed Mammalian Cells
The c-myc proto-oncogene present in mammalian species is expressed in a wide variety of cell types. It consists of three exons (see Fig. 1) of which the first, approximately 560 nucleotides in length, is noncoding although evolutionarily conserved. The c-myc gene product is translated from exons 2 and 3. The transcripts have a size of 2.4 and 2.2 kb that are synthesized under the direction of two promoters, P1 and P2, respectively. Normal c-myc RNAs (Dani et al. 1985) and their 62–64 kDa polypeptide products (Hann and Eisenman 1984) are highly unstable in vivo. The c-myc protein has been localized within the nucleus and has been proposed to contribute to a cell’s competence to enter and progress through the cell cycle (see Moelling, this Vol., and Bravo and Müller, this Vol., and references therein).
KeywordsLymphoma Leukemia Polypeptide Ster Bravo
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