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Regulation of Human Globin Gene Expression

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Oncogenes and Growth Control

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Abstract

At different stages of human development the various globin genes are sequentially activated and expressed in cells of the erythroid lineage. This precisely controlled process raises a number of important issues concerning the molecular basis of gene regulation. These include: (1) the specificity of globin gene expression in erythroid cells; (2) the sequential activation of the different genes within the α-like and β-like globin gene clusters during development, a phenomenon which has been referred to as hemoglobin switching; and (3) the balanced production of α-like and β-like globin polypeptide chains, implying a coordinate expression of genes located on different chromosomes.

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Authors
  1. Patrick Charnay
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Editors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10 22 09, 6900, Heidelberg, Germany

    Patricia Kahn  & Thomas Graf  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Charnay, P. (1986). Regulation of Human Globin Gene Expression. In: Kahn, P., Graf, T. (eds) Oncogenes and Growth Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73325-3_28

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  • DOI: https://doi.org/10.1007/978-3-642-73325-3_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18760-8

  • Online ISBN: 978-3-642-73325-3

  • eBook Packages: Springer Book Archive

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