Clinical Aspects of the Protective Effects of Prostaglandins on Non-Steroidal Anti-Inflammatory Drug-Associated Mucosal Injury

  • D. Y. Graham
Conference paper


Major clinical problems that occur in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) include dyspepsia, gastric (and possibly duodenal) ulcer, gastrointestinal bleeding, and gastric or duodenal perforation. Another problem is that many physicians feel compelled to treat visible mucosal damage associated with the administration of aspirin or other NSAIDs. The pathogenesis of NSAID-induced mucosal damage is still unclear; important variables include NSAID dosage, dosing interval, route of administration, formulation, and the solubility of the compound in the acid milieu of the stomach.


Placebo Sulfide Aspirin Osteoarthritis Prostaglandin 


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© Springer-Verlag Berlin Heidelberg 1988

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  • D. Y. Graham

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