Abstract
The metabolites of arachidonic acid, the eicosanoids, formed by the cyclo-oxygenase and lipoxygenase enzymes exert potent actions on the function and integrity of the gastric mucosa. Since local ischaemia may be involved in the pathogenesis of various forms of gastric damage and ulceration, the local vasodilator actions exerted by many of the anti-ulcer prostanoids such as PGE2 [2] may contribute to the overall process of mucosal protection. A direct action on the vascular endothelium may also contribute, and it has been demonstrated that the potent protective prostanoid, 16,16-dimethyl PGE2, can prevent the microcirculatory stasis induced by the damaging agent ethanol [3].
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References
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© 1988 Springer-Verlag Berlin Heidelberg
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Whittle, B.J.R. (1988). Involvement of the Eicosanoids, Thromboxane A2 and Leukotriene C4 in Gastric Mucosal Damage. In: Domschke, W., Dammann, H.G., Peskar, B.M., Holtermüller, K.H. (eds) Prostaglandins and Leukotrienes in Gastrointestinal Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73316-1_3
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DOI: https://doi.org/10.1007/978-3-642-73316-1_3
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