Skip to main content

Distribution of Exogenous Surfactant in Premature Lambs: High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation

  • Conference paper
Surfactant Replacement Therapy
  • 117 Accesses

Abstract

After tracheal instillation of a surfactant preparation, both preterm animals and infants with respiratory distress syndrome (RDS) respond with a rapid improvement in pulmonary function. Surfactant treatment at birth allows for the mixing of surfactant with lung fluid and leads to an even distribution of surfactant as the lung fluid recedes, whereas the distribution of exogenous surfactant after air breathing is more uneven [1]. Not only the timing of its instillation, but also the type of ventilatory assistance may affect the distribution of exogenous surfactant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jobe A, Ikegami M, Jacobs H, Jones S (1984) Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. J Clin Invest 73: 848–856

    Article  PubMed  CAS  Google Scholar 

  2. Blanco CE, Maertzdorf WJ, Walther FJ (1987) Use of combined high-frequency oscillation and intermittent mandatory ventilation in rabbits with saline-lavaged lungs. J Intensive Care Med 2: 214–217

    Article  Google Scholar 

  3. Walther FJ, Kuipers IM, Gidding CEM, Willebrand D, Buchholtz RTF, Bevers EM (1987) A comparison of high-frequency oscillation superimposed onto backup mechanical ventilation and conventional mechanical ventilation on the distribution of exogenous surfactant in premature lambs. Pediatr Res 22: 725–729

    Article  PubMed  CAS  Google Scholar 

  4. Walther FJ, Blanco CE, Houdjik M, Bevers EM (1985) Single versus repetitive doses of natural surfactant as treatment of respiratory distress syndrome in premature lambs. Pediatr Res 19: 224–227

    Article  PubMed  CAS  Google Scholar 

  5. Boynton BR, Mannino FL, Davis RF, Kopotic RJ, Friederichsen G (1984) Combined high-frequency oscillatory ventilation and intermittent mandatory ventilation in critically ill neonates. J Pediatr 105: 297–302

    Article  PubMed  CAS  Google Scholar 

  6. Bancalari A, Gerhardt T, Bancalari E, Suguihara C, Hehre D, Reifenberg L, Goldberg RN (1987) Gas trapping with high-frequency ventilation: jet versus oscillatory ventilation. J Pediatr 110: 617–622

    Article  PubMed  CAS  Google Scholar 

  7. Solimano A, Bryan C, Jobe A, Ikegami M, Jacobs H (1985) Effects of high frequency and conventional ventilation on the premature lamb lung. J Appl Physiol 59: 1571–1577

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Walther, F.J. (1988). Distribution of Exogenous Surfactant in Premature Lambs: High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation. In: Lachmann, B. (eds) Surfactant Replacement Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73305-5_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73305-5_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73307-9

  • Online ISBN: 978-3-642-73305-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics